Evidence map›Paper›PMID 33410730›Full record

ArticleVirulence2021

Verapamil inhibits efflux pumps in

Yuliana Vega-Chacón, Maria Carolina de Albuquerque, Ana Cláudia Pavarina, Gustavo Henrique Goldman, Ewerton Garcia de Oliveira Mima

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07505446 (Characterization of the Synergistic Antibacterial Effect of Verapamil on Bacterial Isolates From Patients in South Egypt Cancer Institute), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07505446 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Characterization of the Synergistic Antibacterial Effect of Verapamil on Bacterial Isolates From Patients in South Egypt Cancer Institute

TypeobservationalSponsorAssiut UniversityRan2026 to 2027Enrolled100ConditionsMulti Drug Resistant Organisms, Antibiotic ResistanceArmsverapamil
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Identification of efflux inhibitors through a drug repurposing strategy inFrontiers in cellular and infection microbiology · 2026
    Article
  4. Article
  5. Journal of fungi (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Quantification methods ofMicrobial cell (Graz, Austria) · 2024
    Article
  10. Structural and functional investigation of ABC transporter STE6-2p fromProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinicalSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yuliana Vega-ChacónLaboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry , Araraquara, Brazil.ORCID 0000-0001-9370-4151
Maria Carolina de AlbuquerqueLaboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry , Araraquara, Brazil.ORCID 0000-0002-4468-2037
Ana Cláudia PavarinaLaboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry , Araraquara, Brazil.ORCID 0000-0002-9231-1994
Gustavo Henrique GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP) , Ribeirão Preto, Brazil.
Ewerton Garcia de Oliveira MimaLaboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry , Araraquara, Brazil.ORCID 0000-0002-9575-7625
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of resistance requires alternative methods to treat

Indexed as

AnimalsAntifungal AgentsBiofilmsBiological TransportCandida albicansCandidiasisDrug SynergismFluconazoleLarvaMembrane Transport ProteinsMicrobial Sensitivity TestsMothsVerapamilAntifungal AgentsFluconazoleMembrane Transport ProteinsVerapamilCandida albicansdrug resistanceGalleria mellonellamembrane transport proteinsvirulence

Identifiers

PMID33410730
PMCPMC8923067
OpenAlexW3119294016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.