ArticleJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2021
Utilization of Orthobiologics by Sports Medicine Physicians: A Survey-based Study.
Article in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- What Do Patients Know About Orthobiologics? Perceived Efficacy, Safety, and Factors Influencing Treatment Decisions.Orthopaedic journal of sports medicine · 2026Article
- Mapping awareness and application of orthobiologics among orthopaedic professionals: A cross-sectional study.World journal of orthopedics · 2026Article
- A Bundled-Payment Program is Associated with Improved Access to Platelet Rich Plasma for Treatment of Osteoarthritis in Women and Non-White Population Groups.Orthopedic research and reviews · 2026Article
- Common intra-articular knee injections demonstrate a similar recovery trajectory over 60 months: A systematic review and meta-analysis of 15,418 participants.Journal of experimental orthopaedics · 2025Review
- Evidence-based guidelines on orthobiologics.EFORT open reviews · 2025Article
- Orthobiologics Revisited: A Concise Perspective on Regenerative Orthopedics.Current issues in molecular biology · 2025Review
- Narrative review and call to action on reporting and representation in orthobiologics research for knee osteoarthritis.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products.Biomedicines · 2024Review
- Review
- Platelet-rich plasma and other injectables in the young athlete.Journal of the Pediatric Orthopaedic Society of North America · 2024Review
- Patient Outcomes Are Not Improved by Platelet-Rich Plasma Injection Onto the Capsule at the Time of Closure During Hip Arthroscopy for Femoroacetabular Impingement Syndrome.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Biotherapeutic Applications of Platelet-Rich Plasma in Regenerative Medicine.Tissue engineering and regenerative medicine · 2023Review
- The Effect of Amniotic Tissue on Spinal Interventions: A Systematic Review.International journal of spine surgery · 2023Article
- Why and how to use the body's own stem cells for regeneration in musculoskeletal disorders: a primer.Journal of orthopaedic surgery and research · 2022Article
- A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in anJournal of orthopaedics and sports medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInvestigations are rapidly increasing into products referred to as orthobiologics and their utility in the nonsurgical and surgical treatment of diverse orthopaedic pathology.
methodsMembers (599) of the American Orthopaedic Society for Sports Medicine were sent a survey that assessed their usage, motivation for use, and perceived efficacy of the following orthobiologics: leukocyte-rich platelet-rich plasma, leukocyte-poor platelet-rich plasma (PRP-LP), bone marrow aspirate concentrate, amniotic membrane products, adipose-derived mesenchymal stromal cells, and umbilical cord-derived cells. Application of these orthobiologics for the following pathologies was assessed: osteoarthritis, muscle injuries, tendon injuries, ligament injuries, labral injuries, and focal articular cartilage tears.
resultsThe survey was completed by 165 respondents (27.5%), of which 66.1% reported using at least one orthobiologic in their practice. Orthobiologic users reported the following: 71.6% are increasing their use, and 23.9% advertise their use. PRP-LP is the most commonly used orthobiologic for 76.1%, with 30% of PRP-LP users reporting use due to competitor utilization. The pathology most commonly treated with orthobiologics is osteoarthritis, for 71.6% of users, who primarily use PRP-LP in the knee joint. Leukocyte-rich platelet-rich plasma is the most popular orthobiologic in muscle, ligament, tendon, and labral injuries, whereas bone marrow aspirate concentrate is most popular for focal articular cartilage injuries. Primary orthobiologic-eligible groups were adults and recreational noncompetitive athletes. More than half (>50%) of orthobiologic users perceived all but umbilical cord-derived cells to be efficacious.
conclusionOrthobiologics are used by a significant number of sports medicine physicians and are likely increasing in popularity. Among orthobiologics, platelet-rich plasmas are the most popular, and osteoarthritis is the pathology most likely to be treated. Orthobiologics are sometimes used for reasons other than clinical efficacy, especially competitor utilization, and physicians are disparate in their application of these products.
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