Evidence map›Paper›PMID 33410605›Full record

ArticleBrain and behavior2021

Reduced hippocampal volumes and memory deficits in adolescents with single ventricle heart disease.

Nancy A Pike, Bhaswati Roy, Stefanie Moye, Cristina Cabrera-Mino, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nancy A PikeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6198-9957
Bhaswati RoyUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Stefanie MoyeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Cristina Cabrera-MinoUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Nancy J HalnonDivision of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rajesh KumarDepartments of Anesthesiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-5355-9586
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
Memory and Brain Structure in Adolescents with Single Ventricle Heart DiseaseR01NR013930 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIKE, NANCY ANN · 2013 to 2016
$1.4M
NINR NIH HHS R01 NR013930NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

introductionAdolescents with single ventricle congenital heart disease (SVHD) show functional deficits, particularly in memory and mood regulation. Hippocampi are key brain structures that regulate mood and memory; however, their tissue integrity in SVHD is unclear. Our study aim is to evaluate hippocampal volumes and their associations with memory, anxiety, and mood scores in adolescents with SVHD compared to healthy controls.

methodsWe collected brain magnetic resonance imaging data from 25 SVHD (age 15.9 ± 1.2 years; 15 male) and 38 controls (16.0 ± 1.1 years; 19 male) and assessed memory (Wide Range Assessment of Memory and Learning 2, WRAML2), anxiety (Beck Anxiety Inventory, BAI), and mood (Patient Health Questionnaire 9, PHQ-9) functions. Both left and right hippocampi were outlined and global volumes, as well as three-dimensional surfaces were compared between groups using ANCOVA and associations with cognitive and behavioral scores with partial correlations (covariates: age and total brain volume).

resultsThe SVHD group showed significantly higher BAI (p = .001) and PHQ-9 (p < .001) scores, indicating anxiety and depression symptoms and significantly reduced WRAML2 scores (p < .001), suggesting memory deficits compared with controls. SVHD group had significantly reduced right global hippocampal volumes (p = .036) compared with controls, but not the left (p = .114). Right hippocampal volume reductions were localized in the CA1, CA4, subiculum, and dentate gyrus. Positive correlations emerged between WRAML2 scores and left (r = 0.32, p = .01) and right (r = 0.28, p = .03) hippocampal volumes, but BAI and PHQ-9 did not show significant correlations.

conclusionAdolescents with SVHD show reduced hippocampal volumes, localized in several sites (CA1, CA4, subiculum, and dentate gyrus), which are associated with memory deficits. The findings indicate the need to explore ways to improve memory to optimize academic achievement and ability for self-care in the condition.

Indexed as

Heart DiseasesHippocampusAdolescentHumansMagnetic Resonance ImagingMaleMemoryMemory Disorderscognitioncongenital heart diseasegray mattermagnetic resonance imaging

Identifiers

PMID33410605
PMCPMC7882179
OpenAlexW3119983368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.