ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Mediterranean Diet Adherence, Gut Microbiota and Parkinson's Disease: A Systematic Review.Nutrients · 2024Pooled it
- Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies.Nutrients · 2023Pooled it
- Impact of Nationwide Lockdowns Resulting from the First Wave of the COVID-19 Pandemic on Food Intake, Eating Behaviors, and Diet Quality: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- The effect of the Mediterranean diet combined with physical activity on cognitive function in older adults: a scoping review.Journal of the International Society of Sports Nutrition · 2026Article
- Meal-specific dietary patterns relate to memory functioning.Frontiers in nutrition · 2026Article
- Impact of Diverse Dietary Patterns on Cognitive Health: Cumulative Evidence from Prospective Cohort Studies.Nutrients · 2025Review
- Association between dietary inflammatory index score and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies.Biomedicines · 2024Review
- The Mediterranean diet is not associated with neuroimaging or cognition in middle-aged adults: a cross-sectional analysis of the PREVENT dementia programme.European journal of neurology · 2024Article
- The human gut microbiome in critical illness: disruptions, consequences, and therapeutic frontiers.Journal of critical care · 2024Review
- Article
- Nutrition, Immunity and Aging: Current Scenario and Future Perspectives in Neurodegenerative Diseases.CNS & neurological disorders drug targets · 2024Review
- Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology.Neurology · 2023Article
- Thwarting Alzheimer's Disease through Healthy Lifestyle Habits: Hope for the Future.Neurology international · 2023Review
- The Association Between Diet and Cardio-Metabolic Risk on Cognitive Performance: A Cross-Sectional Study of Middle-Aged Australian Adults.Frontiers in nutrition · 2022Article
- Mediterranean diet score is associated with greater allocentric processing in the EPAD LCS cohort: A comparative analysis by biogeographical region.Frontiers in aging · 2022Article
- Effects of Lifestyle Factors on Cognition in Minority Population of Older Adults: A Review.Frontiers in nutrition · 2022Review
- Diet May Moderate the Relationship Between Arterial Stiffness and Cognitive Performance in Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
- DASH diet adherence and cognitive function: Multi-ethnic study of atherosclerosis.Clinical nutrition ESPEN · 2021Article
- Self-Reported Diet and Health Outcomes of Participants of the CCSVI-Tracking Survey Study.Nutrients · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
introductionIt is unclear whether eating Western diet food components offsets the Mediterranean diet's (MedDiet) potential benefits on cognitive decline.
methodsThe study includes 5001 Chicago Health and Aging Project participants (63% African American, 36% males, 74 ± 6.0 years old), with food frequency questionnaires and ≥ two cognitive assessments over 6.3 ± 2.8 years of follow-up. Mixed-effects models were adjusted for age, sex, education, race, cognitive activities, physical activity, and total calories.
resultsStratified analysis showed a significant effect of higher MedDiet on cognitive decline only with a low Western diet score (highest vs lowest MedDiet tertile: β = 0.020, P = .002; p trend = 0.002) and not with a high Western diet score (highest vs lowest MedDiet tertile: β = 0.010, P = .11; p trend = 0.09).
conclusionThis prospective study found that high consumption of Western diet components attenuates benefits of the MedDiet on cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.