ArticleNeurourology and urodynamics2021
Parcellation of human periaqueductal gray at 7-T fMRI in full and empty bladder state: The foundation to study dynamic connectivity changes related to lower urinary tract functioning.
Article in Neurourology and urodynamics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Protocol for a prospective, single-arm pilot trial assessing the clinical and supraspinal neural effects of non-invasive transcranial neuromodulation in adults with overactive bladder.Contemporary clinical trials communications · 2026Article
- What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI-RS 2025.Neurourology and urodynamics · 2026Review
- From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025Review
- Altered Periaqueductal Gray Functional Connectivity in Overactive Bladder Patients: A Resting-State Functional Magnetic Resonance Imaging Study Using Clustering Analysis.International neurourology journal · 2025Article
- The Dynamic Brain in Overactive Bladder: Temporal Evolution of Periaqueductal Gray Connectivity Reveals Neural Rigidity.International neurourology journal · 2025Article
- Spinal Cord Lower Urinary Tract Control in Humans.Neurourology and urodynamics · 2025Article
- A deeper exploration of functional connectivity of brain regions regulating bladder function in healthy adults.Continence (Amsterdam, Netherlands) · 2025Article
- Can the Bladder Itself "Measure" Volume, and Thereby Help to Determine When Initiation of Voiding Should Occur? ICI-RS 2024.Neurourology and urodynamics · 2025Review
- Is the Brainstem Activation Different Between Healthy Young Male and Female Volunteers at Initiation of Voiding? A High Definition 7-Tesla Magnetic Resonance Imaging Study.International neurourology journal · 2023Article
- Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI.Biomedicines · 2023Article
- Between-subject similarity of functional connectivity-based organization of the human periaqueductal gray related to autonomic processing.Frontiers in neuroscience · 2022Article
- Cytoarchitectonic Maps of the Human Metathalamus in 3D Space.Frontiers in neuroanatomy · 2022Article
- Parcellation of human periaqueductal gray at 7-T fMRI in full and empty bladder state: The foundation to study dynamic connectivity changes related to lower urinary tract functioning.Neurourology and urodynamics · 2021Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe periaqueductal gray (PAG) is a brain stem area involved in processing signals related to urine storage and voiding. The PAG is proposed to be responsible for projecting afferent information from the bladder to cortical and subcortical brain areas and acts as a relay station projecting efferent information from cortical and subcortical areas to the pons and spinal cord. Here, we use 7-Tesla functional magnetic resonance imaging to parcellate the PAG into functionally distinct clusters during a bladder filling protocol.
methodsWe assess the similarity between parcellation results in empty and full bladder states and show how these parcellations can be used to create dynamic response profiles of connectivity changes between clusters as a function of bladder sensations.
resultsFor each of our six healthy female participants, we found that the agreement between at least one of the clusters in both states resulting from the parcellation procedure was higher than could be expected based on chance (p ≤ .05), and observed that these clusters are significantly organized in a symmetrical lateralized fashion (p ≤ .05). Correlations between clusters change significantly as a function of experienced sensations during bladder filling (p ≤ .05).
conclusionsThis opens new possibilities to investigate the effects of treatments of lower urinary tract symptoms on signal processing in the PAG, as well as the investigation of disease-specific bladder filling related dynamic signal processing in this small brain structure.
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