ArticleAnnals of neurology2021
Tuber Locations Associated with Infantile Spasms Map to a Common Brain Network.
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Tuberous sclerosis complex.Nature reviews. Disease primers · 2026Review
- Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex.Annals of the Child Neurology Society · 2026Article
- Convolutional neural networks for automatic tuber segmentation and quantification of tuber burden in tuberous sclerosis complex.Epilepsia · 2026Article
- Late-onset epileptic spasms: presentation, aetiology and outcome.Brain communications · 2026Article
- White matter disconnection in acquired criminality.Molecular psychiatry · 2025Article
- Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery.Epilepsy & behavior reports · 2025Article
- Network Localization of Pediatric Lesion-Induced Dystonia.Annals of neurology · 2025Article
- Mapping Lesion-Related Human Aggression to a Common Brain Network.Biological psychiatry · 2025Article
- Prognostic application of lesion network mapping to epilepsy surgery outcomes in pediatric tuberous sclerosis complex.Epilepsia · 2025Article
- Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review.Annals of the Child Neurology Society · 2025Article
- Juvenile Myoclonic Epilepsy Imaging Endophenotypes and Relationship With Cognition and Resting-State EEG.Human brain mapping · 2025Article
- New insights into epileptic spasm generation and treatment from the TTX animal model.Epilepsia open · 2025Article
- Altered cortical excitability in tuberous sclerosis and the effect of mTOR inhibitors: An intracranial electrical stimulation study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.Nature communications · 2025Article
- Accumulated seizure burden predicts neurodevelopmental outcome at 36 months of age in patients with tuberous sclerosis complex.Epilepsia · 2025Article
- Heterogenous brain activations across individuals localize to a common network.Communications biology · 2024Article
- Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial.Pediatric neurology · 2024Article
- Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex.Journal of autism and developmental disorders · 2024Article
- Neural network mapping of gelastic behavior in children with hypothalamus hamartoma.World journal of pediatrics : WJP · 2024Article
- Network localization of pediatric lesion-induced dystonia.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveApproximately 50% of patients with tuberous sclerosis complex develop infantile spasms, a sudden onset epilepsy syndrome associated with poor neurological outcomes. An increased burden of tubers confers an elevated risk of infantile spasms, but it remains unknown whether some tuber locations confer higher risk than others. Here, we test whether tuber location and connectivity are associated with infantile spasms.
methodsWe segmented tubers from 123 children with (n = 74) and without (n = 49) infantile spasms from a prospective observational cohort. We used voxelwise lesion symptom mapping to test for an association between spasms and tuber location. We then used lesion network mapping to test for an association between spasms and connectivity with tuber locations. Finally, we tested the discriminability of identified associations with logistic regression and cross-validation as well as statistical mediation.
resultsTuber locations associated with infantile spasms were heterogenous, and no single location was significantly associated with spasms. However, >95% of tuber locations associated with spasms were functionally connected to the globi pallidi and cerebellar vermis. These connections were specific compared to tubers in patients without spasms. Logistic regression found that globus pallidus connectivity was a stronger predictor of spasms (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 1.10-3.50, p = 0.02) than tuber burden (OR = 1.65, 95% CI = 0.90-3.04, p = 0.11), with a mean receiver operating characteristic area under the curve of 0.73 (±0.1) during repeated cross-validation.
interpretationConnectivity between tuber locations and the bilateral globi pallidi is associated with infantile spasms. Our findings lend insight into spasm pathophysiology and may identify patients at risk. ANN NEUROL 2021;89:726-739.
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