Evidence map›Paper›PMID 33410337›Full record

ArticleJournal of the American Heart Association2021

Short P-Wave Duration is a Marker of Higher Rate of Atrial Fibrillation Recurrences after Pulmonary Vein Isolation: New Insights into the Pathophysiological Mechanisms Through Computer Simulations.

Angelo Auricchio, Tardu Özkartal, Francesca Salghetti, Laura Neumann, Simone Pezzuto, Ali Gharaviri, Andrea Demarchi, Maria Luce Caputo, François Regoli, Carlo De Asmundis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  7. The Value of P-Wave Parameters Changes in Predicting Catheter Ablation Outcomes for Paroxysmal Atrial Fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025
    Article
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  10. Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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  14. Predictive value of interatrial block on electrocardiogram among obese patients undergoing atrial fibrillation ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023
    Article
  15. Electrocardiographic parameters and the risk of new-onset atrial fibrillation in the general population: the Rotterdam Study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Angelo AuricchioDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Tardu ÖzkartalDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Francesca SalghettiHeart Rhythm Management Centre Postgraduate course in Cardiac Electrophysiology and PacingVrije Universiteit BrusselUniversitair Ziekenhuis Brussel Brussels Belgium.
Laura NeumannDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Simone PezzutoCenter for Computational Medicine in Cardiology Università della Svizzera Italiana Lugano Switzerland.
Ali GharaviriCenter for Computational Medicine in Cardiology Università della Svizzera Italiana Lugano Switzerland.
Andrea DemarchiDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Maria Luce CaputoDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
François RegoliDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Carlo De AsmundisHeart Rhythm Management Centre Postgraduate course in Cardiac Electrophysiology and PacingVrije Universiteit BrusselUniversitair Ziekenhuis Brussel Brussels Belgium.
Gian-Battista ChierchiaHeart Rhythm Management Centre Postgraduate course in Cardiac Electrophysiology and PacingVrije Universiteit BrusselUniversitair Ziekenhuis Brussel Brussels Belgium.
Pedro BrugadaHeart Rhythm Management Centre Postgraduate course in Cardiac Electrophysiology and PacingVrije Universiteit BrusselUniversitair Ziekenhuis Brussel Brussels Belgium.
Catherine KlersyService of Clinical Epidemiology & Biometry Fondazione IRCCS Policlinico San Matteo Pavia Italy.
Tiziano MoccettiDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Ulrich SchottenDepartment of Physiology Cardiovascular Research Institute MaastrichtMaastricht University Maastricht The Netherlands.
Giulio ConteDivision of Cardiology Cardiocentro Ticino Lugano Switzerland.
Epatocentro Ticino · CHVrije Universiteit Brussel · BEUniversità della Svizzera italiana · CHMaastricht University · NLOspedale San Giovanni Bellinzona · CHPoliclinico San Matteo Fondazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Short ECG P-wave duration has recently been demonstrated to be associated with higher risk of atrial fibrillation (AF). The aim of this study was to assess the rate of AF recurrence after pulmonary vein isolation in patients with a short P wave, and to mechanistically elucidate the observation by computer modeling. Methods and Results A total of 282 consecutive patients undergoing a first single-pulmonary vein isolation procedure for paroxysmal or persistent AF were included. Computational models studied the effect of adenosine and sodium conductance on action potential duration and P-wave duration (PWD). About 16% of the patients had a PWD of 110 ms or shorter (median PWD 126 ms, interquartile range, 115 ms-138 ms; range, 71 ms-180 ms). At Cox regression, PWD was significantly associated with AF recurrence (

Indexed as

Action PotentialsAtrial FibrillationCatheter AblationHeart Conduction SystemPostoperative ComplicationsAdenosineAnti-Arrhythmia AgentsComputer SimulationElectrocardiographyFemaleHumansMaleMiddle AgedPulmonary VeinsRecurrenceSodium ChannelsAdenosineAnti-Arrhythmia AgentsSodium ChannelsAtrial fibrillationcomputer modellingelectrophysiologypulmonary vein isolationP wave

Identifiers

PMID33410337
PMCPMC7955300
OpenAlexW3118609681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.