Evidence map›Paper›PMID 33410333›Full record

ArticleJournal of the American Heart Association2021

CD4

Joshua A Uhlorn, Nathaniel A Husband, Melissa J Romero-Aleshire, Caitlin Moffett, Merry L Lindsey, Paul R Langlais, Heddwen L Brooks

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  6. Article
  7. βNature communications · 2022
    Article
  8. CD4Journal of the American Heart Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua A UhlornDepartment of Physiology College of Medicine University of Arizona Tucson AZ.
Nathaniel A HusbandDepartment of Physiology College of Medicine University of Arizona Tucson AZ.
Melissa J Romero-AleshireDepartment of Physiology College of Medicine University of Arizona Tucson AZ.
Caitlin MoffettDepartment of Physiology College of Medicine University of Arizona Tucson AZ.
Merry L LindseyDepartment of Cellular and Integrative Physiology Center for Heart and Vascular Research Nebraska-Western Iowa Health Care SystemUniversity of Nebraska Medical Center and Research Service Omaha NE.
Paul R LanglaisDepartment of Medicine College of Medicine University of Arizona Tucson AZ.
Heddwen L BrooksDepartment of Physiology College of Medicine University of Arizona Tucson AZ.
University of Arizona · USNebraska Medical Center · US

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Characterizing the Role of CLASP2 in Insulin-Stimulated Glucose TransportR01DK098493 · NIDDK · UNIVERSITY OF ARIZONA · PI LANGLAIS, PAUL R · 2014 to 2018
$1.8M
T Cell-Mediated Regulation of Blood pressure In Postmenopausal HypertensionR01HL131834 · NHLBI · UNIVERSITY OF ARIZONA · PI BROOKS, HEDDWEN L · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL131834NHLBI NIH HHS T32 HL007249NIDDK NIH HHS R01 DK098493
6 · The paper itself

Abstract

Background Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell-dependent immune activation and development of angiotensin II (Ang II) hypertension, this protection is lost in postmenopausal females. Therefore, the current study hypothesized that specific CD4

Indexed as

CD4-Positive T-LymphocytesHypertensionPostmenopauseAngiotensin IIAnimalsFemaleMAP Kinase Kinase 2MAP Kinase Signaling SystemMiceMice, Inbred C57BLPhosphorylationProteomicsReproductionTalinAngiotensin IIMAP Kinase Kinase 2TalinTln1 protein, mouse4‐vinylcyclohexene diepoxideAng IImenopausephosphoproteomicsproteomicsT cells

Identifiers

PMID33410333
PMCPMC7955317
OpenAlexW3119747744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.