ArticleJournal of the American Heart Association2021
Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysms: A Histopathological Evaluation.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging.International journal of molecular sciences · 2024Pooled it
- Intracranial aneurysm wall enhancement as an indicator of instability: a systematic review and meta-analysis.European journal of neurology · 2021Pooled it
- Intracranial vessel wall MRI in cerebrovascular disease: clarifying its current role in clinical practice.European radiology · 2026Article
- Circumferential wall enhancement is associated with neutrophil-to-lymphocyte ratio in intracranial fusiform aneurysms.Neuroradiology · 2026Article
- Association Between the Systemic Immune-Inflammation Index and Aneurysmal Wall Enhancement on High-Resolution Magnetic Resonance Vessel Wall Imaging in Unruptured Intracranial Aneurysms.Journal of magnetic resonance imaging : JMRI · 2026Article
- Extracellular Vesicles in Stroke: Drivers of Brain-Body Network Crosstalk.Translational stroke research · 2026Review
- A wide-necked saccular aneurysm of the middle cerebral artery bifurcation with neck atherosclerosis mimicking a fusiform aneurysm: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Vessel wall enhancement in brain arteriovenous malformations: associations with imaging and histopathological markers of instability.Neurosurgical review · 2026Article
- Aneurysm Wall Enhancement and Probability of Instability in Unruptured Intracranial Aneurysms: A Long-Term Follow-Up Study.Annals of neurology · 2026Article
- Collagen Imaging in Human Intracranial Aneurysms - a Translational Proof-of-Concept Study.Translational stroke research · 2026Article
- Transformer-based fusion of radiomics-habitat and deep learning for assessing unruptured intracranial aneurysm instability.Frontiers in neuroscience · 2026Article
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Sex difference in predictors of aneurysmal wall enhancement: a cross-sectional and prospective cohort study.Neuroradiology · 2026Article
- Appearance and Disappearance of Intracranial Aneurysm Wall Enhancement during Follow-Up: A Multicenter Cohort Study.AJNR. American journal of neuroradiology · 2025Article
- Comparative analysis and influencing factors of aneurysm wall characteristics based on artificial intelligence-assisted 3.0T MRI and 5.0T MRI high-resolution vascular wall imaging.BMC medical imaging · 2025Article
- Perianeurysmal edema after coil embolization of a giant ruptured aneurysm: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.Science advances · 2025Article
- Comprehensive morphomechanical and wall enhancement analysis of intracranial aneurysms.European radiology · 2025Article
- Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques.Translational stroke research · 2025Review
- There Is Poor Agreement between the Subjective and Quantitative Adjudication of Aneurysm Wall Enhancement.AJNR. American journal of neuroradiology · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Unruptured intracerebral aneurysm wall enhancement (AWE) on vessel wall magnetic resonance imaging scans may be a promising predictor for rupture-prone intracerebral aneurysms. However, the pathophysiology of AWE remains unclear. To this end, the association between AWE and histopathological changes was assessed in this study. Methods and Results A total of 35 patients with 41 unruptured intracerebral aneurysms who underwent surgical clipping were prospectively enrolled. A total of 27 aneurysms were available for histological evaluation. The macroscopic and microscopic features of unruptured intracerebral aneurysms with and without enhancement were assessed. The microscopic features studied included inflammatory cell invasion and vasa vasorum, which were assessed using immunohistochemical staining with CD68, CD3, CD20, and myeloperoxidase for the former and CD34 for the latter. A total of 21 (51.2%) aneurysms showed AWE (partial AWE, n=7; circumferential AWE, n=14). Atherosclerotic and translucent aneurysms were identified in 17 and 14 aneurysms, respectively. Aneurysm size, irregularity, and atherosclerotic and translucent aneurysms were associated with AWE on univariate analysis (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.