ArticleObesity surgery2021
Modulation of the Gut Microbiota and Serum Biomarkers After Laparoscopic Sleeve Gastrectomy: a 1-Year Follow-Up Study.
Article in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis.Obesity surgery · 2023Pooled it
- Postbiotics: emerging regulatory mechanisms and therapeutic applications in obesity and its complications.International journal of obesity (2005) · 2026Review
- Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity.International journal of obesity (2005) · 2026Article
- Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss.Gut microbes · 2025Article
- Altered cognitive function in obese patients: relationship to gut flora.Molecular and cellular biochemistry · 2025Review
- Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.Nutrients · 2024Review
- Article
- Changes in the Gut Microbiota Composition and Their Relation to Dietary Intake After Bariatric Surgery.Obesity surgery · 2023Article
- State of art on the mechanisms of laparoscopic sleeve gastrectomy in treating type 2 diabetes mellitus.World journal of diabetes · 2023Review
- Metagenomics Characterization ofJournal of arthropod-borne diseases · 2023Article
- Brazilian guide to nutrition in bariatric and metabolic surgery.Langenbeck's archives of surgery · 2023Article
- Bariatric Surgery as Treatment Strategy of Obesity in Saudi People: Effects of Gut Microbiota.Nutrients · 2023Article
- Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives.Biomolecules · 2021Review
- Bariatric Surgery and Liver Disease: General Considerations and Role of the Gut-Liver Axis.Nutrients · 2021Review
- Gut Microbiome and Metabolites in Patients with NAFLD and after Bariatric Surgery: A Comprehensive Review.Metabolites · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBariatric surgery is a treatment option for those affected by severe obesity. This study investigated changes in gut microbiota and serum biomarkers after laparoscopic sleeve gastrectomy (LSG). MATERIALS AND
methodsA total of 126 patients with morbid obesity who underwent LSG were enrolled in this study. Routine biochemical tests, hormonal (insulin and glucagon), and cytokine levels (IL-6, IL-1β, TNF-α, IL-10, and TGF-β 1) were measured, in addition, real-time PCR (quantitative PCR, qPCR) quantitated gut microbiota. All the parameters were measured pre-operatively, 3, and 12 months post-surgery (F0, F3, and F12, respectively).
resultsAt F3, the level of FBS, HbA1c, HOMA-IR, triglyceride, cholesterol, LDL, BUN, creatinine, urea, SGOT, SGPT, IL-1β, IL-6, IFNγ, insulin, glucagon, the abundance of Prevotella and Bacteroides fragilis group, as well as the concentration of Firmicutes spp. showed significant decrease (P < 0.01), and HDL level, Akkermansia muciniphila and Roseburia spp. abundance, and Bacteroidetes and Bifidobacterium spp. concentration showed significant increase (P < 0.0001). The observed pattern continued or remained stable at F12 for all of these variables. IL-10 and TGF-β1 remained unchanged until F3 and showed a significant drop at F12. At F3, Clostridium cluster IV increased significantly and remained at that level afterward. Moreover, concentration of Phylum Actinobacteria showed an initial drop at F3 and a later increase at F12 (P < 0.0001).
conclusionLSG is associated with a significant improvement in serum biomarkers, as well as significant changes in fecal microbiota. Future systems biology analyses would shed more light on the underlying interactions of these parameters, and could help in developing novel diagnostic and therapeutic strategies for obesity management.
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