Evidence map›Paper›PMID 33409915›Full record

ArticleBiological trace element research2021

Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer.

Aleksandar Stojsavljević, Branislav Rovčanin, Jovana Jagodić, Đurđa Krstić, Ivan Paunović, Marija Gavrović-Jankulović, Dragan Manojlović

Abstract read
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In one paragraph

Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  7. Elemental comparative analysis of 18 elements reveal distinct patterns in benign and malignant thyroid tissues.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Aleksandar StojsavljevićDepartment for Analytical Chemistry, Innovation Center, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia. aleksandars@chem.bg.ac.rs.ORCID http://orcid.org/0000-0002-6221-3437
Branislav RovčaninCenter for Endocrine Surgery, Clinical Center of Serbia, Koste Todorovica 8, Belgrade, Serbia.
Jovana JagodićDepartment for Analytical Chemistry, Innovation Center, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
Đurđa KrstićDepartment for Analytical Chemistry, Innovation Center, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
Ivan PaunovićCenter for Endocrine Surgery, Clinical Center of Serbia, Koste Todorovica 8, Belgrade, Serbia.
Marija Gavrović-JankulovićDepartment for Analytical Chemistry, Innovation Center, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
Dragan ManojlovićDepartment for Analytical Chemistry, Innovation Center, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11000, Serbia.
University of Belgrade · RSSouth Ural State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification model, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases.

Indexed as

Endocrine DisruptorsGoiterThyroid DiseasesThyroid NeoplasmsTrace ElementsHumansEndocrine DisruptorsTrace ElementsMultinodular goiterThyroid adenomaThyroid cancerTrace elements

Identifiers

PMID33409915
OpenAlexW3118511399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.