Evidence map›Paper›PMID 33409831›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Hearing loss and dementia: radiologic and biomolecular basis of their shared characteristics. A systematic review.

Arianna Di Stadio, Massimo Ralli, Dalila Roccamatisi, Alfonso Scarpa, Antonio Della Volpe, Claudia Cassandro, Giampietro Ricci, Antonio Greco, Evanthia Bernitsas

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Sensory impairment and dementia risk among older adults in rural South Africa.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Review
  7. Hearing Loss and Alzheimer Disease.Current topics in behavioral neurosciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Aging Brain and Hearing: A Mini-Review.Frontiers in aging neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Arianna Di StadioOtolaryngology Department, University of Perugia, Perugia, Italy. ariannadistadio@hotmail.com.ORCID http://orcid.org/0000-0001-5510-3814
Massimo RalliDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Dalila RoccamatisiPsychology Department, Università Telematica Internazionale Uninettuno (UTIU), Rome, Italy.
Alfonso ScarpaDepartment of Otolaryngology, University of Salerno, Salerno, Italy.
Antonio Della VolpeOtology and Cochlear Implant Unit, Santobono-Pausilipon Hospital of Naples, Naples, Italy.
Claudia CassandroDepartment of Otolaryngology, University of Turin, Turin, Italy.
Giampietro RicciOtolaryngology Department, University of Perugia, Perugia, Italy.
Antonio GrecoDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Evanthia BernitsasNeurology Department, Wayne State University, Detroit, MI, USA.
Sapienza University of Rome · ITUniversity of Perugia · ITUniNettuno University · ITUniversity of Salerno · ITUniversity of Turin · ITWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia and hearing loss share radiologic and biologic findings that might explain their coexistence, especially in the elderly population. Brain atrophy has been observed in both conditions, as well as the presence of areas of gliosis. The brain atrophy is usually focal; it is located in the temporal lobe in patients with hearing loss, while it involves different part of brain in patients with dementia. Radiological studies have shown white matter hyperintensities (WMHs) in both conditions. WMHs have been correlated with the inability to correctly understand words in elderly persons with normal auditory thresholds and, the identification of these lesion in brain magnetic resonance imaging studies has been linked with an increased risk of developing cognitive loss. In addition to WMHs, some anatomopathological studies identified the presence of brain gliosis in the elderly's brain. The cause-effect link between hearing loss and dementia is still unknown, despite they might share some common findings. The aim of this systematic review is to analyze radiologic and biomolecular findings that these two conditions might share, identify a common pathological basis, and discuss the effects of hearing aids on prevention and treatment of cognitive decline in elderly patients with hearing loss.

Indexed as

Cognitive DysfunctionDementiaHearing LossAgedAtrophyBrainHumansMagnetic Resonance ImagingBrain atrophyCognitive declineHearing lossWhite matter lesion

Identifiers

PMID33409831
OpenAlexW3118594578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.