Evidence map›Paper›PMID 33409819›Full record

SynthesisBrain imaging and behavior2021

Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.

David F Tate, Emily L Dennis, John T Adams, Maheen M Adamson, Heather G Belanger, Erin D Bigler, Heather C Bouchard, Alexandra L Clark, Lisa M Delano-Wood, Seth G Disner and 31 more

Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06381674 (Wearable Technology to Characterize and Treat mTBI Subtypes), which is not on this map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06381674 narecruitingnot on this mapstarted 2024, after this paper: background citation

Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation

TypeinterventionalSponsorOregon Health and Science UniversityRan2024 to 2028Enrolled100ConditionsMild Traumatic Brain Injury, Concussion, Rehabilitation, Balance ImpairmentArmsVestibular therapy for mTBI augmented with audio and visual real-time biofeedback, Vestibular therapy for mTBI
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 5 countries.

David F TateDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. david.tate@hsc.utah.edu.ORCID http://orcid.org/0000-0003-0213-1920
Emily L DennisDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
John T AdamsWestern University of Health Sciences, Pomona, CA, USA.
Maheen M AdamsonDefense and Veterans Brain Injury Center, VA Palo Alto, Palo Alto, CA, USA.
Heather G BelangerUnited States Special Operations Command (USSOCOM), Tampa, FL, USA.
Erin D BiglerDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Heather C BouchardDuke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Alexandra L ClarkVA San Diego Healthcare System, San Diego, CA, USA.
Lisa M Delano-WoodVA San Diego Healthcare System, San Diego, CA, USA.
Seth G DisnerDepartment of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.
Blessen C EapenDepartment of Physical Medicine and Rehabilitation, VA Greater Los Angeles Health Care System, Los Angeles, CA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Elbert GeuzeUniversity Medical Center Utrecht, Utrecht, Netherlands.
Naomi J Goodrich-HunsakerDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Kihwan HanSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Jasmeet P HayesPsychology Department, The Ohio State University, Columbus, OH, USA.
Sidney R HindsDepartment of Defense/United States Army Medical Research and Materiel Command, Fort Detrick, Frederick, MD, USA.
Cooper B HodgesDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Elizabeth S HovendenDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrei IrimiaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kimbra KenneyDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Inga K KoertePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Harvey S LevinH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Hannah M LindseyDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Rajendra A MoreyDuke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Mary R NewsomeH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
John OllingerNational Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Mary Jo PughInformation Decision-Enhancement and Analytic Sciences Center, VA Salt Lake City, Salt Lake City, UT, USA.
Randall S ScheibelH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Danielle R SullivanNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.
Brian A TaylorDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Maya TroyanskayaH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Carmen VelezDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Benjamin Sc WadeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Xin WangDepartment of Psychiatry, University of Toledo, Toledo, OH, USA.
Ashley L WareDepartment of Psychology, University of Calgary, Calgary, Alberta, Canada.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, Massachusetts General Hospital/Brigham & Women's Hospital, Boston, MA, USA.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
Elisabeth A WildeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
University of Utah · USBrigham Young University · USMichael E. DeBakey VA Medical Center · USUniversity of California San Diego · USBrigham and Women's Hospital · USDuke University · USUniformed Services University of the Health Sciences · USUniversity of California, Los Angeles · USBaylor College of Medicine · USBoston University · USLAC+USC Medical Center · USMinneapolis VA Health Care System · USPalo Alto Veterans Institute for Research · USThe Ohio State University · USThe University of Texas at Dallas · USUniversity Medical Center Utrecht · NLUniversity of Calgary · CAUniversity of Southern California · USUniversity of South Florida · USUniversity of Toledo · US

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Study of early brain alterations that predict development of chronic PTSDR01MH110483 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WANG, XIN · 2016 to 2021
$3.8M
Neuroimaging and Molecular Markers of AD and Neurodegenerative Disease after ConcussionR01AG058822 · NIA · OHIO STATE UNIVERSITY · PI Jasmeet Pannu Hayes · 2019 to 2026
$2.7M
Advancing Secondary Data Analysis: the ENIGMA Brain Injury Data Harmonization InitiativeR61NS120249 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DENNIS, EMILY LARSEN, HILLARY, FRANK GERARD · 2020 to 2021
$1.9M
Effects of blood-brain barrier disruption upon white matter connectivity subsequent to traumatic brain injuryR01NS100973 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI IRIMIA, ANDREI · 2017 to 2021
$1.6M
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
CENC- Longitudinal Cohort StudyI01CX001135 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI BELANGER, HEATHER G, CIFU, DAVID X. · 2015 to 2019
–
Exploring polygenic risk as a means for personalizing TBI rehabilitationIK2RX002922 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI DISNER, SETH GORDON · 2019 to 2024
–
Neural Metabolic Stress in mTBI and PTSDIK2CX001772 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SULLIVAN, DANIELLE R · 2018 to 2022
–
CSRD VA I01 CX001135CSRD VA I01 CX001820CSRD VA IK2 CX001772NCATS NIH HHS UL1 TR002649NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG058822NIBIB NIH HHS U54 EB020403NIH HHS R01AG058822NIH HHS R01NS100973NIH HHS U54EB020403NIH HHS UL1TR002649NIMH NIH HHS R01 MH110483NINDS NIH HHS K99 NS096116NINDS NIH HHS K99NS096116NINDS NIH HHS R01 NS100973NINDS NIH HHS R61 NS120249RRD VA I01 RX002174RRD VA I01 RX003442RRD VA I01 RX003443RRD VA IK2 RX002922
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal, diffuse or combination of injury to the brain. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in this patient population. The purpose of this manuscript is to describe both the challenges and opportunities when conducting military-relevant TBI research and introduce the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Military Brain Injury working group. ENIGMA is a worldwide consortium focused on improving replicability and analytical power through data sharing and collaboration. In this paper, we discuss challenges affecting efforts to aggregate data in this patient group. In addition, we highlight how "big data" approaches might be used to understand better the role that each of these variables might play in the imaging and functional phenotypes of TBI in Service member and Veteran populations, and how data may be used to examine important military specific issues such as return to duty, the late effects of combat-related injury, and alteration of the natural aging processes.

Indexed as

Brain Injuries, TraumaticMilitary PersonnelStress Disorders, Post-TraumaticVeteransHumansMagnetic Resonance Imagingblast injuryENIGMAmilitaryTBItraumatic brain injuryveteran

Identifiers

PMID33409819
PMCPMC8035292
OpenAlexW3120302636

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.