ArticleEuropean radiology2021
Breast density, benign breast disease, and risk of breast cancer over time.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2022Pooled it
- Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta-Analysis.Health science reports · 2026Article
- Article
- Breast cancer risk assessment for screening: a hybrid artificial intelligence approach.European radiology · 2026Article
- Comparative spectral analysis of blood and saliva in breast cancer, benign breast disease and healthy controls using ATR-FTIR.Scientific reports · 2026Article
- Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy.Breast cancer research : BCR · 2026Article
- Predicting radiological regression in benign breast hyperplasia: the prolactin-to-estradiol ratio as a prognostic biomarker.Frontiers in medicine · 2026Article
- What is the significance of a new breast mass in women aged 40 or above? A cross-sectional study.PloS one · 2026Article
- Impact of Endocrine Therapy on Osteoporosis Risk in Women with Breast Cancer Across Different Hormonal Stages: A Review.Current oncology (Toronto, Ont.) · 2025Review
- Personalized screening based on risk and density: prevalence data from the RIBBS study.La Radiologia medica · 2025Observational
- Analysis of Lifestyle and Genetic Risk Factors in Urban Women in China Who Had Malignant or Suspected Malignant Breast Nodules Identified via Breast Cancer Screening.Breast care (Basel, Switzerland) · 2025Article
- A systematic review of determinants of breast cancer risk among women with benign breast disease.NPJ breast cancer · 2025Article
- Development and validation of the surmising model for volumetric breast density using X-ray exposure conditions in digital mammography.Medical & biological engineering & computing · 2025Article
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- Mammographic assessment of breast density as a tool for predicting the response to neoadjuvant therapy in breast cancer patients.Medicine and pharmacy reports · 2024Article
- Clinical application of ultrasound-guided thoracic nerve block in the operation of benign breast tumors.American journal of translational research · 2023Article
- An ultrasound-based radiomics model to distinguish between sclerosing adenosis and invasive ductal carcinoma.Frontiers in oncology · 2023Article
- Use of Breast Cancer Risk Factors to Identify Risk-Adapted Starting Age of Screening in China.JAMA network open · 2022Article
- A Case Study in Breast Density Evaluation Using Bioimpedance Measurements.Sensors (Basel, Switzerland) · 2022Article
- Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesAssessing the combined effect of mammographic density and benign breast disease is of utmost importance to design personalized screening strategies.
methodsWe analyzed individual-level data from 294,943 women aged 50-69 years with at least one mammographic screening participation in any of four areas of the Spanish Breast Cancer Screening Program from 1995 to 2015, and followed up until 2017. We used partly conditional Cox models to assess the association between benign breast disease, breast density, and the risk of breast cancer.
resultsDuring a median follow-up of 8.0 years, 3697 (1.25%) women had a breast cancer diagnosis and 5941 (2.01%) had a benign breast disease. More than half of screened women had scattered fibroglandular density (55.0%). The risk of breast cancer independently increased with the presence of benign breast disease and with the increase in breast density (p for interaction = 0.84). Women with benign breast disease and extremely dense breasts had a threefold elevated risk of breast cancer compared with those with scattered fibroglandular density and without benign breast disease (hazard ratio [HR] = 3.07; 95%CI = 2.01-4.68). Heterogeneous density and benign breast disease was associated with nearly a 2.5 elevated risk (HR = 2.48; 95%CI = 1.66-3.70). Those with extremely dense breast without a benign breast disease had a 2.27 increased risk (95%CI = 2.07-2.49).
conclusionsWomen with benign breast disease had an elevated risk for over 15 years independently of their breast density category. Women with benign breast disease and dense breasts are at high risk for future breast cancer. KEY POINTS: • Benign breast disease and breast density were independently associated with breast cancer. • Women with benign breast disease had an elevated risk for up to 15 years independently of their mammographic density category.
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