Evidence map›Paper›PMID 33409726›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Effectiveness of a nurse-led telephone follow-up in the therapeutic management of patients receiving oral antineoplastic agents: a randomized, multicenter controlled trial (ETICCO study).

Wafa Bouleftour, Thierry Muron, Aline Guillot, Fabien Tinquaut, Romain Rivoirard, Jean-Philippe Jacquin, Léa Saban-Roche, Karima Boussoualim, Emmanuelle Tavernier, Karine Augeul-Meunier and 7 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02459483 (Evaluation of a Telephone Care Nurse in the Management of Patients With Cancer and Treated by Oral Chemotherapy), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02459483 naunknown statusnot on this map

Evaluation of a Telephone Care Nurse in the Management of Patients With Cancer and Treated by Oral Chemotherapy

TypeinterventionalSponsorInstitut de Cancérologie de la LoireRan2015 to 2018Enrolled184ConditionsCancerArmsNurse phone call
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Effectiveness of mHealth apps on adherence and symptoms to oral anticancer medications: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wafa BouleftourMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France. wafa.bouleftour@icloire.fr.ORCID https://orcid.org/0000-0002-8485-9386
Thierry MuronMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Aline GuillotMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Fabien TinquautCentre Hygée, Public Health Department, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Romain RivoirardMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Jean-Philippe JacquinMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Léa Saban-RocheMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Karima BoussoualimDepartment of Rheumatology, North Hospital, University Hospital of Saint-Étienne, 42270, Saint-Priest-en-Jarez, France.
Emmanuelle TavernierDepartment of Clinical Hematology, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Karine Augeul-MeunierDepartment of Clinical Hematology, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Olivier CollardMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Benoite MeryMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
Sidonie PupierCentre Hygée, Public Health Department, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Mathieu OriolCentre Hygée, Public Health Department, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Aurélie BourmaudCentre Hygée, Public Health Department, Lucien Neuwirth Cancer Institute, 42270, Saint-Priest-en-Jarez, France.
Pierre FournelMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.
C VassalMedical Oncology Department, Lucien Neuwirth Cancer Institute, 108 bis Avenue Albert Raimond, 42270, Saint Priest en Jarez, France.

Funding

La ligue contre le cancer NA« Le réseau espace santé cancer Rhones-Alpes: INNOV'RA 2014 », NANovartis Pharma SAS NA
6 · The paper itself

Abstract

purposeThe use of oral cancer drugs (OAD) has increased over the last two decades. The objective of this study was to measure the impact of a nurse-led telephone follow-up in the therapeutic management of patients treated with an OAD regarding toxicity, medication adherence and quality of life.

methodsA randomized, multicenter, controlled trial was conducted. All consecutive over 18-year-old patients, treated in medical oncology, radiotherapy, or hematology departments, receiving OAD for any cancer were invited to participate to the study. A total of 183 patients treated for solid or hematological cancers with an OAD were randomly assigned to receive a nurse-led telephone follow-up or standard care for 24 weeks. Data were collected between 2015 and 2018.

resultsNurse telephone follow-up did not improve the global score toxicity in the intervention group. However, telephone calls directed by trained nurses induced a significant decrease in number of patients with grade 3 adverse events throughout the follow-up [OR 0.45 (IC à 95%) (0.23, 0.9)](P = 0.03). There was no significant difference in quality of life and medication adherence between groups at any follow-up time point.

conclusionsIn this first French real-life study, the advice provided by qualified nurses via phone calls improved the management of grade 3 toxicities but failed to demonstrate an improvement of all grades of toxicities. More prospective studies are needed to confirm the impact of telephone calls on the toxicities related to OAD.

trial registrationClinical trial registration is NCT02459483. Protection committee SUD-ESTI registration is 2015-A00527-42 on 13 April 2015. National Agency for the Safety of Medicines and Health Products registration is 150619-B on the 27 may 2015.

Indexed as

AgedAntineoplastic AgentsFemaleFollow-Up StudiesHumansMaleMedication AdherenceMiddle AgedProspective StudiesQuality of LifeAntineoplastic AgentsEducation of patientsOral antineoplastic drugsSafety monitoringSide-effect preventionTelephone

Identifiers

PMID33409726

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.