ArticleSurgical case reports2021
Spontaneous regression of breast cancer with immune response: a case report.
Article in Surgical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Spontaneous Dramatic Regression of Clear Cell Renal Cell Carcinoma After Pazopanib-Induced Severe Systemic Inflammatory Syndrome: A Case Report and Literature Review.Current oncology (Toronto, Ont.) · 2025Review
- MHC class II-mediated spontaneous rejection of breast carcinomas expressing model neoantigens.Journal for immunotherapy of cancer · 2025Article
- Spontaneous Regression of Locally Advanced Breast Cancer Following Cardiopulmonary Arrest: A Case Report.Cureus · 2025Article
- Transient Regression of Breast Carcinoma After Diagnostic Biopsy and Tumor Heterogeneity: A Case Report.Cureus · 2024Article
- Article
- The type 2 inflammatory response favors recognition of tumor antigens by IgE in breast cancer.Cancer reports (Hoboken, N.J.) · 2024Article
- Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review.Gland surgery · 2023Article
- What Can Trigger Spontaneous Regression of Breast Cancer?Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous regression (SR) is a rare phenomenon in which a cancer disappears or remits without treatment. We report a case of breast cancer that showed spontaneous tumor regression in the surgical specimen after core needle biopsy. CASE PRESENTATION: A 59-year-old woman came to our hospital complaining of a painful lump in the right breast. In the upper-outer quadrant of the right breast, a tumor with an unclear boundary, 30 mm in diameter, was palpable. In pathological findings from needle biopsy, the tumor was diagnosed as solid-type invasive ductal breast carcinoma. Partial coagulation necrosis was generated in estrogen receptor-negative, HER2-negative, and AE1/AE3-positive ductal carcinoma without infiltration of lymphocytes. Surgery for right breast cancer was then performed. Histological examination of the surgical specimen revealed the tumor was invasive ductal carcinoma with lymphocyte infiltration, coagulation necrosis, and fibrous tissue with hemosiderin. The tumor formed a solid nest, 3 mm in diameter, suggesting the possibility of SR.
conclusionsImmune responses, infection, hormones, surgical stress, and ischemia have been reported as mechanisms of SR. The findings in this case strongly suggest that SR of breast cancer is associated with anti-tumor immune responses.
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