Evidence map›Paper›PMID 33409625›Full record

ArticleParasitology research2021

Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Göttingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova).

M V Prosberg, H Kringel, J S Kapel, B S Kapel, B L Fredensborg, A M Petersen, L H Hansen, D S Nielsen, H S Kapel, K R Jacobsen and 2 more

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Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

M V ProsbergDepartment of Gastroenterology, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650, Hvidovre, Denmark.
H KringelParaTech A/S, Dr. Neergaards Vej 3, 2970, Hoersholm, Denmark. hek@para-tech.dk.ORCID http://orcid.org/0000-0003-4682-1114
J S KapelParaTech A/S, Dr. Neergaards Vej 3, 2970, Hoersholm, Denmark.
B S KapelParaTech A/S, Dr. Neergaards Vej 3, 2970, Hoersholm, Denmark.
B L FredensborgDepartment of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark.
A M PetersenDepartment of Gastroenterology, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650, Hvidovre, Denmark.
L H HansenDepartment of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark.
D S NielsenDepartment of Food Science, University of Copenhagen, Copenhagen, Denmark.
H S KapelParaTech A/S, Dr. Neergaards Vej 3, 2970, Hoersholm, Denmark.
K R JacobsenEllegaard Göttingen Minipigs A/S, Soroe Landevej 302, 4261, Dalmose, Denmark.
L F MikkelsenEllegaard Göttingen Minipigs A/S, Soroe Landevej 302, 4261, Dalmose, Denmark.
C M O KapelParaTech A/S, Dr. Neergaards Vej 3, 2970, Hoersholm, Denmark.
University of Copenhagen · DKHvidovre Hospital · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The probiotic medicinal product TSO (Trichuris suis ova) is administered to patients with active ulcerative colitis in an ongoing clinical phase IIb trial where the typical co-medications are steroids (prednisolone or budesonide) and antibiotics (e.g., phenoxymethylpenicillin). The present pre-clinical study evaluates the effects of these co-medications on the biological activity of TSO in Göttingen Minipigs. This translationally relevant pre-clinical model allows administration of TSO with and without oral steroids or antibiotics in a manner similar to the administration to patients, followed by quantification of the biological activity of TSO. The biological activity of TSO was not affected by oral steroids but was reduced by oral antibiotics. Fecal calprotectin, the common marker of intestinal inflammation in patients with UC, did not differ between groups.

Indexed as

TrichurisAnimalsAnti-Bacterial AgentsColitis, UlcerativeDisease Models, AnimalFemaleOvumProbioticsSteroidsSwineSwine, MiniatureAnti-Bacterial AgentsSteroidsAntibioticsSteroidsTrichuris suis ova (TSO)Ulcerative colitis

Identifiers

PMID33409625
OpenAlexW3119729025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.