ArticleiScience2021
Spinal motor mapping by epidural stimulation of lumbosacral posterior roots in humans.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06295614 (Study on Preliminary Safety and Efficacy of the ARC-IM Therapy to Alleviate Locomotor Deficits in People With Parkinson's Disease), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Preliminary Safety and Efficacy of the ARC-IM Therapy to Alleviate Locomotor Deficits in People With Parkinson's Disease
Who cites it
35 citing papers in PubMed, 45 citations in OpenAlex.
- Functional outcomes and participants' perspectives during short-term application of spinal stimulation in individuals with spinal cord injury.The journal of spinal cord medicine · 2025Trial
- From Trial to Chronic Epidural Electrical Stimulation: A Single-Patient Feasibility Study in Motor-Complete Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Article
- Partitioning of the nervous system following exoskeleton and epidural stimulation in spinal cord injury.Scientific reports · 2026Article
- Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury.Journal of neurophysiology · 2026Article
- Spinal Cord Stimulation Improves Deceleration Phase Control during Targeted Reaching Post-Stroke.Research square · 2026Article
- The Interplay Between Neuromodulation and Stem Cell Therapy for Sensory-Motor Neuroplasticity After Spinal Cord Injury: A Perspective View.Journal of clinical medicine · 2026Article
- Immediate Effects of Transcutaneous Spinal Stimulation on Stretch-Induced Spasticity in Persons with Spinal Cord Injury.Brain sciences · 2025Article
- Spinal Cord Stimulation Improves Feedback Control of Reaching Post-Stroke.medRxiv : the preprint server for health sciences · 2025Article
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Characterizing spinal reflexes evoked by sensory spinal cord stimulation in people with lower-limb amputation.Journal of neuroengineering and rehabilitation · 2025Article
- Differential modulation of trunk muscle activation using thoracic epidural spinal stimulation.Journal of neural engineering · 2025Article
- Grid-based transcutaneous spinal cord stimulation: probing neuromodulatory effect in spinal flexion reflex circuits.Journal of neural engineering · 2025Article
- An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation.Journal of neural engineering · 2025Article
- Epidural Stimulation and Resistance Training (REST-SCI) for Overground Locomotion After Spinal Cord Injury: Randomized Clinical Trial Protocol.Journal of clinical medicine · 2025Article
- Role of Epidural Electrode Stimulation in Three Patients with Incomplete AIS D Spinal Cord Injury.Biomedicines · 2025Article
- Correlating Evoked Electromyography and Anatomic Factors During Spinal Cord Stimulation Implantation With Short-Term Outcomes.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Transcutaneous spinal cord stimulation neuromodulates pre- and postsynaptic inhibition in the control of spinal spasticity.Cell reports. Medicine · 2024Article
- MRI Spinal Cord Reconstruction Provides Insights into Mapping and Migration Following Percutaneous Epidural Stimulation Implantation in Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Targeted Selection of Stimulation Parameters for Restoration of Motor and Autonomic Function in Individuals With Spinal Cord Injury.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidural electrical stimulation of the spinal cord is an emergent strategy for the neurological recovery of lower-extremity motor function. Motoneuron pools are thought to be recruited by stimulation of posterior roots. Here, we linked electromyographic data of epidurally evoked lower-extremity responses of 34 individuals with upper motoneuron disorders to a population model of the spinal cord constructed using anatomical parameters of thousands of individuals. We identified a relationship between segmental stimulation sites and activated spinal cord segments, which made spinal motor mapping from epidural space possible despite the complex anatomical interface imposed by the posterior roots. Our statistical approach provided evidence for low-threshold sites of posterior roots and effects of monopolar and bipolar stimulation previously predicted by computer modeling and allowed us to test the impact of different upper motoneuron disorders on the evoked responses. Finally, we revealed a statistical association between intraoperative and postoperative mapping of the spinal cord.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.