Evidence map›Paper›PMID 33409457›Full record

ArticleJNCI cancer spectrum2020

Effects of Breast Cancer Adjuvant Chemotherapy Regimens on Expression of the Aging Biomarker,

Shlomit S Shachar, Allison M Deal, Katherine E Reeder-Hayes, Kirsten A Nyrop, Natalia Mitin, Carey K Anders, Lisa A Carey, E Claire Dees, Trevor A Jolly, Gretchen G Kimmick and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
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  4. p16GeroScience · 2026
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  19. Does walking during chemotherapy impact p16Journal of clinical laboratory analysis · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Shlomit S ShacharRambam Health Campus, School of Medicine, Haifa, Israel.
Allison M DealLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-3526-3938
Katherine E Reeder-HayesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kirsten A NyropLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Natalia MitinSapere Bio, Research Triangle Park, NC, USA.
Carey K AndersSchool of Medicine, Duke University, Durham, NC, USA.
Lisa A CareyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-2388-4649
E Claire DeesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Trevor A JollyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-2900-848X
Gretchen G KimmickSchool of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0001-7096-9624
Meghan S KaruturiMD Anderson Cancer Center, University of Texas, Houston, TX, USA.
Raquel E ReinboltComprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
JoEllen C SpecaUNC Rex Healthcare, Raleigh, NC, USA.
Hyman B MussLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-2862-9970
University of North Carolina at Chapel Hill · USDuke University · USRambam Health Care Campus · ILResearch Triangle Park Foundation · USRex Hospital · USThe Ohio State University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Biomarkers of Molecular Age to Predict the Toxicity of Cancer ChemotherapyR01CA203023 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MUSS, HYMAN · 2016 to 2020
$2.5M
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA203023
6 · The paper itself

Abstract

backgroundAlthough chemotherapy saves lives, increasing evidence shows that chemotherapy accelerates aging. We previously demonstrated that mRNA expression of

methodsWe conducted a study of stage I-III breast cancer patients receiving adjuvant or neoadjuvant chemotherapy.

resultsIn 146 women, chemotherapy was associated with a statistically significant increase in

conclusionsOur findings suggest that the aging effects of chemotherapy may be influenced by both chemotherapy type and the patient's baseline

Identifiers

PMID33409457
PMCPMC7771421
OpenAlexW3114061532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.