ArticleJournal of vitreoretinal diseases2020
Quantifying Subclinical and Longitudinal Microvascular Changes Following Episcleral Plaque Brachytherapy Using Spectral Domain-Optical Coherence Tomography Angiography.
Article in Journal of vitreoretinal diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Trial
- Radiation retinopathy: a review.International ophthalmology · 2026Review
- Retinal and Optic-Disc Changes Associated With ¹³¹I Therapy in Papillary Thyroid Carcinoma and Their Determinants.Investigative ophthalmology & visual science · 2026Article
- Review
- Review
- Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma.American journal of ophthalmology case reports · 2022Article
- OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment.Frontiers in digital health · 2022Article
- Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow.Translational vision science & technology · 2021Article
- OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess longitudinal microvascular changes in eyes treated with I-125 episcleral plaque brachytherapy (EPB).
methodsHigh resolution OCT angiograms of the central 3×3mm macula were obtained from I-125 episcleral plaque brachytherapy treated and untreated fellow eyes of 61 patients. Capillary density (vessel skeleton density, VSD) and caliber (vessel diameter index, VDI) were quantified using previously validated semi-automated algorithms. Nonperfusion was also quantified as flow impairment regions (FIR). Exams from treated and fellow eyes obtained pre-treatment and at 6-month, 1-year, and 2-year intervals were compared using generalized estimating equation linear models. Dosimetry maps were used to evaluate spatial correlation between radiation dose and microvascular metrics.
resultsAt 6 months, treated eyes had significantly lower VSD (0.145 ± 0.003 vs 0.155 ± 0.002;
conclusionsOCTA can be used to quantify and monitor EPB induced retinopathy, and can detect vascular abnormalities even in the absence of clinically observable retinopathy. OCTA may therefore be useful in investigating treatment interventions that aim to delay EPB-induced radiation retinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.