Evidence map›Paper›PMID 33409439›Full record

ArticleJournal of the Endocrine Society2021

Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism.

María Belén Zanchetta, Damián Robbiani, Beatriz Oliveri, Evangelina Giacoia, Adriana Frigeri, Silvia Kallsbrum, Helena Salerni, Sabrina Lucas, Adriana Diaz, Betiana Perez and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Skeletal and nonskeletal consequences of hypoparathyroidism.Archives of endocrinology and metabolism · 2022
    Review
  9. Review
  10. Clinical Presentation of Hypoparathyroidism.Journal of the Endocrine Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

María Belén ZanchettaIDIM, Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina.ORCID 0000-0002-9397-1847
Damián RobbianiIDIM, Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina.
Beatriz OliveriMautalen, Salud e Investigación, Buenos Aires, Argentina.
Evangelina GiacoiaServicio de Endocrinología y Metabolismo, Hospital Posadas, Provincia de Buenos Aires, Argentina.
Adriana FrigeriUnidad de Endocrinología, Hospital Dr T. Alvarez, Buenos Aires, Argentina.
Silvia KallsbrumServicio de Endocrinología, Hospital Carlos G Durand, Buenos Aires, Argentina.
Helena SalerniServicio de Endocrinología, Hospital Carlos G Durand, Buenos Aires, Argentina.
Sabrina LucasSección Osteopatías Médicas, División Endocrinología de Clínicas José de San Martin-UBA, Buenos Aires, Argentina.
Adriana DiazSección Osteopatías Médicas, División Endocrinología de Clínicas José de San Martin-UBA, Buenos Aires, Argentina.
Betiana PerezServicio de Endocrinología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Luisina PieroniUnidad de Endocrinología, Hospital Dr T. Alvarez, Buenos Aires, Argentina.
María Auxiliadora Arce LangeUnidad de Endocrinología, Hospital Dr T. Alvarez, Buenos Aires, Argentina.
Silvina TormoServicio de Endocrinología y Metabolismo, Hospital Posadas, Provincia de Buenos Aires, Argentina.
Ariela KitaigrodskyServicio de Endocrinología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Ana María GalichServicio de Endocrinología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Hospital General de Agudos Dr. TEODORO ALVAREZ · ARHospital Italiano de Buenos Aires · AREl Hospital General de Agudos Carlos G. Durand · ARHospital de Clínicas "José de San Martín" · ARHospital Posadas · ARUniversidad del Salvador · ARHelios Salud · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextHypoparathyroidism is a rare disease and, as such, its natural history, long-term complications, and correct clinical management remain unclear.

objectiveTo describe the natural history and clinical characteristics of the disease. DESIGN AND

settingTo present a retrospective observational analysis from 7 specialized centers in Buenos Aires, Argentina. PATIENTS: Chronic hypoparathyroid patients followed-up between 1985 and December 2018.

main outcome measuresData on demographics, etiology, clinical complications, biochemical parameters, dual-energy x-ray absorptiometry (DXA) values, and treatment doses were collected.

resultsA total of 322 subjects with chronic hypoparathyroidism were included; 85.7% were female, the mean age was 55.2 ± 16.8 years, and the mean age at diagnosis was 43.8 ± 16.8 years. Prevalence of surgical hypoparathyroidism was 90.7%, with the most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7% of the whole group and in 4.3% of patients who had a history of seizures. Overall, 40.9% of our patients had reported at least 1 neuromuscular symptom. Renal insufficiency was present in 22.4% of our patients and was significantly associated with age (

conclusionAlthough these patients were followed-up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70% of the study's group of patients met the experts' indications for considering the use of rhPTH 1-84. Being aware of this fact is the 1

Indexed as

hyperphosphatemiahypocalcemiahypoparathyroidismPTH

Identifiers

PMID33409439
PMCPMC7774093
OpenAlexW3108159386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.