ArticleNetwork neuroscience (Cambridge, Mass.)2020
Damage to the structural connectome reflected in resting-state fMRI functional connectivity.
Article in Network neuroscience (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Distributed network flows generate localized category selectivity in human visual cortex.PLoS computational biology · 2024Article
- A phenomenological model of whole brain dynamics using a network of neural oscillators with power-coupling.Scientific reports · 2023Article
- Genuine high-order interactions in brain networks and neurodegeneration.Neurobiology of disease · 2022Article
- Mapping correlated neurological deficits after stroke to distributed brain networks.Brain structure & function · 2022Review
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Edge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery.NeuroImage. Clinical · 2022Article
- Structural connectome constrained graphical lasso for MEG partial coherence.Network neuroscience (Cambridge, Mass.) · 2022Article
- Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection.NeuroImage · 2021Article
- Predicting Post-Stroke Somatosensory Function from Resting-State Functional Connectivity: A Feasibility Study.Brain sciences · 2021Article
- A Transcriptome Community-and-Module Approach of the Human Mesoconnectome.Entropy (Basel, Switzerland) · 2021Article
- Independent contributions of structural and functional connectivity: Evidence from a stroke model.Network neuroscience (Cambridge, Mass.) · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
The relationship between structural and functional connectivity has been mostly examined in intact brains. Fewer studies have examined how differences in structure as a result of injury alters function. In this study we analyzed the relationship of structure to function across patients with stroke among whom infarcts caused heterogenous structural damage. We estimated relationships between distinct brain regions of interest (ROIs) from functional MRI in two pipelines. In one analysis pipeline, we measured functional connectivity by using correlation and partial correlation between 114 cortical ROIs. We found fMRI-BOLD partial correlation was altered at more edges as a function of the structural connectome (SC) damage, relative to the correlation. In a second analysis pipeline, we limited our analysis to fMRI correlations between pairs of voxels for which we possess SC information. We found that voxel-level functional connectivity showed the effect of structural damage that we could not see when examining correlations between ROIs. Further, the effects of structural damage on functional connectivity are consistent with a model of functional connectivity, diffusion, which expects functional connectivity to result from activity spreading over multiple edge anatomical paths.
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