Evidence map›Paper›PMID 33409418›Full record

ArticleGlobal health & medicine2020

Nucleos(t)ide reverse transcriptase inhibitor-sparing regimens in the era of standard 3-drug combination therapies for HIV-1 infection.

Keita Uchitsubo, Junichi Masuda, Tsubasa Akazawa, Risako Inoue, Kunihisa Tsukada, Hiroyuki Gatanaga, Hiroyuki Terakado, Shinichi Oka

Open access · bronzeAbstract read
In one paragraph

Article in Global health & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.0field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Keita UchitsuboPharmaceutical Department, National Center for Global Health and Medicine, Tokyo.
Junichi MasudaPharmaceutical Department, National Center for Global Health and Medicine, Tokyo.
Tsubasa AkazawaPharmaceutical Department, National Center for Global Health and Medicine, Tokyo.
Risako InouePharmaceutical Department, National Center for Global Health and Medicine, Tokyo.
Kunihisa TsukadaAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo.
Hiroyuki GatanagaAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo.
Hiroyuki TerakadoPharmaceutical Department, National Center for Global Health and Medicine, Tokyo.
Shinichi OkaAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo.
National Center for Global Health and Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleos(t)ide reverse transcriptase inhibitor (NRTI)-sparing regimens have often been selected as antiretroviral therapy (ART) for HIV-1 infection recently, but data for characteristics have been lacking. This study aimed to document the current status of NRTI-sparing regimens in the era of standard 3-drug combination therapies. We cross-sectionally compared characteristics of patients treated with NRTI-sparing regimens (NRTI-sparing group) with dolutegravir plus tenofovir alafenamide fumarate/emtricitabine as a standard ART group in 2018. The NRTI-sparing and the standard ART groups included 61 and 469 patients, respectively. The mean (± standard deviation) age and serum creatinine of the NRTI-sparing group were significantly higher than those of the standard ART group (57.6 ± 12.8 years vs 42.8 ± 10.4 years (

Indexed as

agingantiretroviral therapyrenal function

Identifiers

PMID33409418
PMCPMC7780279
OpenAlexW3091898825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.