Evidence map›Paper›PMID 33409398›Full record

ReviewTranslational gastroenterology and hepatology2021

Gut microbiome changes in Nonalcoholic fatty liver disease & alcoholic liver disease.

Eric K Kwong, Puneet Puri

Open access · diamondAbstract readReview
In one paragraph

Review in Translational gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  12. Review
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  14. Current Medical Treatment for Alcohol-Associated Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eric K KwongDepartment of Microbiology and Immunology, McGuire VA Medical Center, Richmond, VA, USA.
Puneet PuriSection of Gastroenterology, Hepatology and Nutrition, McGuire VA Medical Center, Richmond, VA, USA.
Hunter Holmes McGuire VA Medical Center · USVirginia Commonwealth University · US

Funding

Effect of alcohol on obesity related liver disease: Role of intestinal metabonomeK23AA021179 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI PURI, PUNEET · 2012 to 2016
$882k
The role of Sphingosine Kinase 2 in alcoholic liver diseaseF30AA026470 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KWONG, ERIC KWUN · 2017 to 2020
$170k
NIAAA NIH HHS F30 AA026470NIAAA NIH HHS K23 AA021179
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are some of the most common liver diseases worldwide. The human gut microbiome is dynamic and shifts in bacterial composition have been implicated in many diseases. Studies have shown that there is a shift in bacterial overgrowth favoring pro-inflammatory mediators in patients with advanced disease progression such as cirrhosis. Further investigation demonstrated that the transplantation of gut microbiota from advanced liver disease patients can reproduce severe liver inflammation and injury in mice. Various techniques in manipulating the gut microbiota have been attempted including fecal transplantation and probiotics. This review focuses on the changes in the gut microbiota as well as emerging lines of microbiome work with respect to NAFLD and ALD.

Indexed as

alcoholic fatty liver diseaseMicrobiomenonalcoholic fatty liver disease (NAFLD)

Identifiers

PMID33409398
PMCPMC7724179
OpenAlexW3036785920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.