ArticleJournal of advanced veterinary and animal research2020
Administration of neem (
Article in Journal of advanced veterinary and animal research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024Article
- Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases.Nutrients · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to determine the neem leaf extract's effect on Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-6 (IL-6) expressions in dextran sodium sulfate (DSS)-induced colitis rats. MATERIALS AND
methodsIn the first phase of the study, colitis was induced by DSS administration in the case group and compared to the control group. In the second phase, 84 colitis rats were divided into groups I, II, and III receiving 7.8 mg/day of mesalazine, 100 mg/200 gm body weight, and 200 mg/200 gm body weight neem leaf extract, respectively.
resultsTNF-α and IL-6 expressions were significantly increased in the case group compared to the control group. TNF-α and IL-6 expressions were decreasing in all groups receiving treatment. Group III showed an earlier decrease compared to group II. TNF-α and IL-6 expressions in group III were comparable with group I since the second week. This condition was observed in the 4th week between group II and group I.
conclusionIt can be concluded that neem leaf extract decreased the expression of TNF-α and IL-6 in DSS-induced colitis.
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