Evidence map›Paper›PMID 33409158›Full record

ArticleFrontiers in cellular and infection microbiology2020

Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke.

Lei Xiang, Yanfeng Lou, Lingyu Liu, Yuanling Liu, Weizheng Zhang, Jianxin Deng, Yubin Guan, Miaoqin She, Xinchao You, Minqi Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lei XiangDepartment of Integrative Chinese and Western Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Yanfeng LouDepartment of Dermatology, Jinling Hospital, Southern Medical University, Nanjing, China.
Lingyu LiuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Yuanling LiuAdministrative Department, Guangdong Province Hospital for Women and Children Healthcare, Guangzhou, China.
Weizheng ZhangClinical Laboratory, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Jianxin DengDepartment of Endocrinology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen, China.
Yubin GuanClinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Miaoqin SheResearch Section, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Xinchao YouGuangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Minqi LiuClinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Hongwei LiInstitute of Biotherapy, Southern Medical University, Guangzhou, China.
Xiaosong XuClinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Fang LiuDepartment of Dermatology, Jinling Hospital, Southern Medical University, Nanjing, China.
Xiangsheng CaiClinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that features of the gut microbiota correlate with ischemic stroke. However, the specific characteristics of the gut microbiota in patients suffering different types of ischemic stroke, or recovering from such strokes, have rarely been studied, and potential microbiotic predictors of different types of stroke have seldom been analyzed. We subjected fecal specimens from patients with lacunar or non-lacunar acute ischemic infarctions, and those recovering from such strokes, to bacterial 16S rRNA sequencing and compared the results to those of healthy volunteers. We identified microbial markers of different types of ischemic stroke and verified that these were of diagnostic utility. Patients with two types of ischemic stroke, and those recovering from ischemic stroke, exhibited significant shifts in microbiotic diversities compared to healthy subjects. Cluster of Orthologous Groups of Proteins (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed reduced metabolic and transport-related pathway activities in ischemic stroke patients. We performed fivefold cross-validation using a Random Forest model to identify two optimal bacterial species (operational taxonomic units; OTUs) serving as markers of lacunar infarction; these were

Indexed as

Brain IschemiaIschemic StrokeStrokeStroke, LacunarHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Sacute ischemic infarctiongut microbiotalacunar infarctionnon-lacunar acute ischemic infarctionpost-ischemic strokerandom forest model

Identifiers

PMID33409158
PMCPMC7779606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.