Evidence map›Paper›PMID 33408950›Full record

ArticleACS catalysis2019

A Bacterial β1-3-Galactosyltransferase Enables Multigram-Scale Synthesis of Human Milk Lacto-

John B McArthur, Hai Yu, Xi Chen

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Microbial Production of Human Milk Oligosaccharides.Molecules (Basel, Switzerland) · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Synthesis as an Expanding Resource in Human Milk Science.Journal of the American Chemical Society · 2021
    Review
  18. Article
  19. Review
  20. Transglycosylation Activity of EngineeredInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John B McArthurDepartment of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-5032-4412
Hai YuDepartment of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-4378-0532
Xi ChenDepartment of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-3160-614X
University of California, Davis · US

Funding

Chemoenzymatic synthesis of bacterial polysaccharidesU01GM125288 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIESSLING, LAURA L, LI, LEI · 2017 to 2020
$3.1M
Facile chemoenzymatic synthesis and purification of glycolipidsU01GM120419 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2016 to 2019
$2.8M
NIGMS NIH HHS U01 GM120419NIGMS NIH HHS U01 GM125288
6 · The paper itself

Abstract

β1-3-Linked galactosides such as Galβ1‒3GlcNAcβOR are common carbohydrate motifs found in human milk oligosaccharides (HMOSs), glycolipids, and glycoproteins. Efficient and scalable enzymatic syntheses of these structures have proven challenging due to the lack of access to a highly active β1‒3-galactosyltransferase (β3GalT) in large amounts. Previously reported

Indexed as

biocatalysisenzymatic synthesisglycosyltransferasehuman milk oligosaccharideLNT

Identifiers

PMID33408950
PMCPMC7785058
OpenAlexW2981587775

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.