Evidence map›Paper›PMID 33408791›Full record

ArticleTheranostics2021

Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability.

Qinyanqiu Xiang, Bin Qiao, Yuanli Luo, Jin Cao, Kui Fan, Xinghua Hu, Lan Hao, Yang Cao, Qunxia Zhang, Zhigang Wang

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
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  7. Article
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  10. Innovative strategies for photodynamic therapy against hypoxic tumor.Asian journal of pharmaceutical sciences · 2023
    Review
  11. Article
  12. Article
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  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Qinyanqiu XiangInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Bin QiaoInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Yuanli LuoInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Jin CaoInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Kui FanDepartment of Nephrology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Xinghua HuDepartment of Neurosurgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Lan HaoInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Yang CaoInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Qunxia ZhangInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Zhigang WangInstitute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Second Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) efficacy in cancer cells is affected by sub-physiological hypoxia caused by dysregulated and "chaotic" tumor microvasculature. However, current traditional O

Indexed as

Adenosine TriphosphateAnimalsApoptosisBreast NeoplasmsCell ProliferationFemaleHumansMiceMice, Inbred BALB CMice, NudeNanoparticlesNitric OxidePhotochemotherapyPhotosensitizing AgentsPolyestersTumor Cells, CulturedAdenosine TriphosphateNitric OxidePhotosensitizing AgentsPolyesterspoly(lactide)nitric oxidephotodynamic therapy, hypoxia relief, mitochondrial respiration, adenosine triphosphate

Identifiers

PMID33408791
PMCPMC7778583
OpenAlexW3110976158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.