ArticleTheranostics2021
Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis.
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Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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Who cites it
51 citing papers in PubMed, 89 citations in OpenAlex.
- A Novel Loss-of-Function Variant inGenes · 2026Article
- NICD3 mediates pro-angiogenic effects through SMAD3/TGFBI axis in colorectal cancer.Cell death & disease · 2026Article
- Transforming growth factor β induced as a novel secreted immune checkpoint counterinhibiting human tumor-associated T cells.Journal for immunotherapy of cancer · 2026Article
- Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development.Current issues in molecular biology · 2026Review
- TGFBI deficiency facilitates tumor associated macrophages M2 polarization and angiogenesis to promote pancreatic neuroendocrine neoplasms progression.Cancer cell international · 2026Article
- Navigating the Tumor Microenvironment in Colorectal Liver Metastasis: Barriers to Therapy and Emerging Opportunities.Oncology research · 2026Review
- Smoking-Induced STC2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- TGFBI in tumors and the tumor immune microenvironment: functional roles, mechanisms, and therapeutic targeting.Frontiers in immunology · 2026Review
- Multi-omics integration reveals hypoxia-driven mechanisms in vascular dementia: a machine learning and single-cell sequencing approach.Annals of medicine and surgery (2012) · 2025Article
- Differences in Expression of Epithelial-Mesenchymal Transition (EMT) Induction Genes TGF-Β Pathway Transition in Colorectal Cancer Patients Non-Metastatic and Metastatic.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Identification of Common Cancer Antigens Useful for Specific Immunotherapies to Colorectal Cancer and Liver Metastases.International journal of molecular sciences · 2025Article
- Identification of parthanatos-related molecular subtypes and development of prognostic risk models in ovarian cancer based on multi-omics analysis.Journal of ovarian research · 2025Article
- Mechanism of Curcumol Targeting the OTUB1/TGFBI Ubiquitination Pathway in the Inhibition of Angiogenesis in Colon Cancer.International journal of molecular sciences · 2025Article
- Multi-omics analysis to uncover the molecular basis of tumor budding in head and neck squamous cell carcinoma.NPJ precision oncology · 2025Article
- Identification of Core SASP-Related Genes TGFBI and ANXA6 for Diagnosing Ulcerative Colitis-Related Colorectal Cancer Through Machine Learning.Journal of inflammation research · 2025Article
- Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer.Frontiers in bioinformatics · 2025Article
- Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis.Cancer medicine · 2024Article
- TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities.International journal of molecular sciences · 2024Review
- Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids.Protein & cell · 2024Article
- Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
26 authors at 8 institutions in 5 countries.
Barbara ChiavarinaCancer Research Institute of Montpellier, Tumor Microenvironment and Resistance to Treatment Laboratory, INSERM U1194, Montpellier, France.
Brunella CostanzaMetastasis Research Laboratory, GIGA Cancer, University of Liège, Liège, Belgium.
Roberto RoncaUniversity of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy.
Arnaud BlommeMetastasis Research Laboratory, GIGA Cancer, University of Liège, Liège, Belgium.
Sara RezzolaUniversity of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy.
Paola ChiodelliUniversity of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy.
Ambre GiguelayCancer Research Institute of Montpellier, Tumor Microenvironment and Resistance to Treatment Laboratory, INSERM U1194, Montpellier, France.
Guillame BelthierInstitut National de la Santé et de la Recherche Médicale, Montpellier, France.
Gilles DoumontCenter for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), rue Adrienne Bolland 8, B-6041 Charleroi (Gosselies), Belgium.
Gaetan Van SimaeysCenter for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), rue Adrienne Bolland 8, B-6041 Charleroi (Gosselies), Belgium.
Simon LacroixCenter for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), rue Adrienne Bolland 8, B-6041 Charleroi (Gosselies), Belgium.
Takehiko YokoboriGunma University Initiative for Advanced Research, International Open Laboratory, Universities of Liege and Montpellier Laboratory, Gunma University, Gunma, Japan.
Bilguun Erkhem-OchirGunma University Initiative for Advanced Research, International Open Laboratory, Universities of Liege and Montpellier Laboratory, Gunma University, Gunma, Japan.
Patrick BalaguerInstitut National de la Santé et de la Recherche Médicale, Montpellier, France.
Vincent CavaillesInstitut National de la Santé et de la Recherche Médicale, Montpellier, France.
Eric FabbrizioInstitut National de la Santé et de la Recherche Médicale, Montpellier, France.
Emmanuel Di ValentinGIGA-Viral Vectors Platform, University of Liège, Liège, Belgium.
Stephanie GofflotBIOTHEQUE, University of Liege, Liege, Belgium.
Olivier DetryDepartment of Abdominal Surgery, University Hospital, University of Liège, Liège, Belgium.
Guy JerusalemDepartment of Medical Oncology, University Hospital, University of Liège, Liège, Belgium.
Serge GoldmanCenter for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), rue Adrienne Bolland 8, B-6041 Charleroi (Gosselies), Belgium.
Philippe DelvenneDepartment of Pathology, University Hospital, University of Liège, Liège, Belgium.
Akeila BellahcèneMetastasis Research Laboratory, GIGA Cancer, University of Liège, Liège, Belgium.
Julie PannequinInstitut National de la Santé et de la Recherche Médicale, Montpellier, France.
Vincent CastronovoMetastasis Research Laboratory, GIGA Cancer, University of Liège, Liège, Belgium.
Andrei TurtoiCancer Research Institute of Montpellier, Tumor Microenvironment and Resistance to Treatment Laboratory, INSERM U1194, Montpellier, France.
University of Liège · BEUniversité de Montpellier · FRErasmus Hospital · BEUniversity of Brescia · ITGunma University · JPInserm · FRInstitut de Recherche en Cancérologie de Montpellier · FRCentre Hospitalier Universitaire de Liège · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due to mutations in the receptors and/or downstream signaling molecules. TGFβ influences CRC cells only indirectly via stromal cells, such as cancer-associated fibroblasts. However, CRC cell ability to directly respond to TGFβ currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions.
Indexed as
Gene Expression Regulation, NeoplasticAnimalsApoptosisbetaIG-H3 ProteinBiomarkers, TumorCell MovementCell ProliferationColorectal NeoplasmsExtracellular Matrix ProteinsHumansLiver NeoplasmsMiceNeovascularization, PathologicPrognosisSignal TransductionTransforming Growth Factor betabetaIG-H3 ProteinBiomarkers, TumorExtracellular Matrix ProteinsTransforming Growth Factor betaalternative TGFβ signalingendothelial cellsliver metastases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.