Evidence map›Paper›PMID 33408769›Full record

ArticleTheranostics2021

Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia.

Huizhong Xiong, Maicol Mancini, Michael Gobert, Shiqian Shen, Glaucia C Furtado, Sergio A Lira, Christopher N Parkhurst, Veronique Garambois, Muriel Brengues, Carlos E Tadokoro and 11 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Huizhong XiongKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Maicol ManciniInstitut de Recherche en Cancérologie de Montpellier (IRCM), Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, 34298, Cedex 5, France.
Michael GobertKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Shiqian ShenKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Glaucia C FurtadoImmunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sergio A LiraImmunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Christopher N ParkhurstKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Veronique GaramboisInstitut de Recherche en Cancérologie de Montpellier (IRCM), Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, 34298, Cedex 5, France.
Muriel BrenguesInstitut de Recherche en Cancérologie de Montpellier (IRCM), Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, 34298, Cedex 5, France.
Carlos E TadokoroKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Thomas TrimarchiDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Gonzalo Gómez-LópezBioinformatics unit. Spanish National Cancer Research Center (CNIO). Madrid, Spain.
Amartya SinghRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
Hossein KhiabanianRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
Sonia MinuzzoDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Stefano IndraccoloVeneto Institute of Oncology IOV - IRCCS, Padova, Italy.
Camille LobryDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Iannis AifantisDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Daniel HerranzRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
Juan J LafailleKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Antonio MaraverInstitut de Recherche en Cancérologie de Montpellier (IRCM), Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, 34298, Cedex 5, France.
New York University · USIcahn School of Medicine at Mount Sinai · USJohnson University · USHoward Hughes Medical Institute · USIstituti di Ricovero e Cura a Carattere Scientifico · ITRutgers, The State University of New Jersey · USUniversity of Padua · IT

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Gut Microbiota Influences Postoperative Cognitive Dysfunction through Indole-3-Propionic AcidR35GM128692 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2018 to 2022
$2.2M
Development and Validation of a Clinically Relevant Animal Pain ModelR61NS116423 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2020 to 2020
$420k
Aging Promotes Pain Chronification through Changes in PGC-1alpha Expression and Interneuron DysfunctionR03AG067947 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2020 to 2021
$336k
NCI NIH HHS P30 CA016087NIA NIH HHS R03 AG067947NIGMS NIH HHS R35 GM128692NINDS NIH HHS R61 NS116423
6 · The paper itself

Abstract

The Notch pathway is highly active in almost all patients with T-cell acute lymphoblastic leukemia (T-ALL), but the implication of Notch ligands in T-ALL remains underexplored.

Indexed as

Gene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingAnimalsApoptosisBiomarkers, TumorCalcium-Binding ProteinsCell ProliferationFemaleHumansMiceMice, Inbred NODMice, SCIDPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptors, NotchSpleenTumor Cells, CulturedAdaptor Proteins, Signal TransducingBiomarkers, TumorCalcium-Binding ProteinsDLL4 protein, humanReceptors, NotchdemcizumabDLL4Notch pathwaypatient-derived xenograftsT-ALL

Identifiers

PMID33408769
PMCPMC7778594
OpenAlexW3111043336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.