Evidence map›Paper›PMID 33408713›Full record

ReviewFrontiers in immunology2020

Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Florian Tran, Christine Klein, Alexander Arlt, Simon Imm, Evelyn Knappe, Alison Simmons, Philip Rosenstiel, Philip Seibler

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Tumor organoid-immune cell co-culture systems for precision oncology.Frontiers in cell and developmental biology · 2026
    Review
  2. Skin Organoids in Diabetic Chronic Wounds: Current Status and Future Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  3. Review
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  7. Modification of Lhx2 activity forFrontiers in cell and developmental biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Florian TranInstitute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Alexander ArltKlinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
Simon ImmInstitute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
Evelyn KnappeInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Alison SimmonsMRC Human Immunology Unit (MRC), University of Oxford, Oxford, United Kingdom.
Philip RosenstielInstitute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
Philip SeiblerInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
University of Lübeck · DEMRC Human Immunology Unit · GBUniversity Hospital Schleswig-Holstein · DE

Funding

Medical Research Council MC_PC_MR/S025952/1Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/7Medical Research Council MR/S036377/1
6 · The paper itself

Abstract

Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells

Indexed as

Precision MedicineRegenerationStem Cell TransplantationTissue EngineeringAnimalsCell CommunicationCell DifferentiationCells, CulturedCoculture TechniquesDiffusion of InnovationHumansInflammationOrganoidsSignal TransductionTissue Culture Techniquescancerco-culturehost-microbeimmune-epithelial interactionsinduced pluripotent stem cellspatient derived organoidsprecision medicinestem cell

Identifiers

PMID33408713
PMCPMC7779798
OpenAlexW3118030408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.