ArticleFrontiers in physiology2020
The Human Organism as an Integrated Interaction Network: Recent Conceptual and Methodological Challenges.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Direct causality measures unravel complex networks of cardiovascular dynamics and their modifications with postural stress.PLoS computational biology · 2026Article
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Beyond hypertrophy: a network physiology perspective on the cardio-neuromuscular trade-off in elite soccer.Frontiers in network physiology · 2026Article
- Metastability in the mixing/demixing of two species with reciprocally concentration-dependent diffusivity.Frontiers in network physiology · 2025Article
- Editorial: Reviews in networks in the brain system.Frontiers in network physiology · 2024Article
- Testing dynamic correlations and nonlinearity in bivariate time series through information measures and surrogate data analysis.Frontiers in network physiology · 2024Article
- Quantifying the Resilience of a Healthcare System: Entropy and Network Science Perspectives.Entropy (Basel, Switzerland) · 2023Article
- Intercorrelated variability in blood and hemodynamic biomarkers reveals physiological network in hemodialysis patients.Scientific reports · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Modifying functional brain networks in focal epilepsy by manual visceral-osteopathic stimulation of the vagus nerve at the abdomen.Frontiers in network physiology · 2023Article
- Perspectives on Understanding Aberrant Brain Networks in Epilepsy.Frontiers in network physiology · 2022Article
- Towards a Data-Driven Estimation of Resilience in Networked Dynamical Systems: Designing a Versatile Testbed.Frontiers in network physiology · 2022Article
- A Sedentary and Unhealthy Lifestyle Fuels Chronic Disease Progression by Changing Interstitial Cell Behaviour: A Network Analysis.Frontiers in physiology · 2022Article
- From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science.Frontiers in endocrinology · 2022Review
- Effects of Acute Partial Sleep Deprivation and High-Intensity Interval Exercise on Postprandial Network Interactions.Frontiers in network physiology · 2022Article
- The New Field of Network Physiology: Building the Human Physiolome.Frontiers in network physiology · 2021Article
- Measuring the Rate of Information Exchange in Point-Process Data With Application to Cardiovascular Variability.Frontiers in network physiology · 2021Article
- Health and Disease Are Dynamic Complex-Adaptive States Implications for Practice and Research.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of Network Physiology aims to advance our understanding of how physiological systems and sub-systems interact to generate a variety of behaviors and distinct physiological states, to optimize the organism's functioning, and to maintain health. Within this framework, which considers the human organism as an integrated network, vertices are associated with organs while edges represent time-varying interactions between vertices. Likewise, vertices may represent networks on smaller spatial scales leading to a complex mixture of interacting homogeneous and inhomogeneous networks of networks. Lacking adequate analytic tools and a theoretical framework to probe interactions within and among diverse physiological systems, current approaches focus on inferring properties of time-varying interactions-namely strength, direction, and functional form-from time-locked recordings of physiological observables. To this end, a variety of bivariate or, in general, multivariate time-series-analysis techniques, which are derived from diverse mathematical and physical concepts, are employed and the resulting time-dependent networks can then be further characterized with methods from network theory. Despite the many promising new developments, there are still problems that evade from a satisfactory solution. Here we address several important challenges that could aid in finding new perspectives and inspire the development of theoretic and analytical concepts to deal with these challenges and in studying the complex interactions between physiological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.