Evidence map›Paper›PMID 33408510›Full record

ArticleJournal of pain research2020

Post-Cesarean Delivery Analgesic Outcomes in Patients Maintained on Methadone and Buprenorphine: A Retrospective Investigation.

Joseph L Reno, Michael Kushelev, Julie H Coffman, Mona R Prasad, Avery M Meyer, Kristen M Carpenter, Marilly S Palettas, John C Coffman

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06784180 (Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06784180 phase4withdrawnnot on this mapstarted 2026, after this paper: background citation

Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2026 to 2029Enrolled0ConditionsOpioid Use DisorderArmsMorphine, Bupivacaine, Fentanyl, Hydromorphone
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Joseph L RenoDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7591-2325
Michael KushelevDepartment of Anesthesiology, The Ohio State University Medical Center, Columbus, OH, USA.ORCID 0000-0001-5022-3155
Julie H CoffmanDepartment of Internal Medicine, Riverside Methodist Hospital, Columbus, OH, USA.
Mona R PrasadDepartment of OBGYN, OhioHealth, Columbus, OH, USA.
Avery M MeyerDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kristen M CarpenterDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Marilly S PalettasCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
John C CoffmanDepartment of Anesthesiology, The Ohio State University Medical Center, Columbus, OH, USA.ORCID 0000-0001-9245-8585
The Ohio State University Wexner Medical Center · USRiverside Methodist Hospital · USOhioHealth · USThe Ohio State University · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD).

methodsPatients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution from 2011 to 2018 were identified. Anesthetic details and analgesic outcomes, including daily opioid consumption and pain scores, were compared between patients maintained on buprenorphine and methadone. Analgesic outcomes were also evaluated according to anesthetic type (neuraxial or general anesthesia) and daily buprenorphine/methadone dose to determine if these factors impacted pain after delivery.

resultsA total of 146 patients were included (buprenorphine n=99 (67.8%), methadone n=47 (32.2%)). Among all patients: 74% had spinal/CSE, 15% epidural, and 11% general anesthesia. Anesthesia types were similar among buprenorphine and methadone patients. For spinal anesthetics, intrathecal fentanyl (median 15 µg) and morphine (median 100 µg) were commonly given (97.2% and 96.3%, respectively), and dosed similarly between groups. Among epidural anesthetics, epidural morphine (median 2 mg) was commonly administered (90.9%), while fentanyl (median 100 µg) was less common (54.5%). Buprenorphine and methadone groups consumed similar amounts of oxycodone equivalents per 24 hours of hospitalization (80.6 vs 76.3 mg;

conclusionPatients on buprenorphine and methadone had similar high opioid consumption and pain scores after CD. The anesthetic details and analgesic outcomes reported in this investigation may serve as a useful reference for future prospective investigations and aid in the clinical care of these patients.

Indexed as

buprenorphinecesarean analgesiaenhanced recoverymethadoneopioid use disorderoutcomes

Identifiers

PMID33408510
PMCPMC7779306
OpenAlexW3113878666

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.