ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Aberrant triple-network connectivity patterns discriminate biotypes of first-episode medication-naive schizophrenia in two large independent cohorts.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2023Pooled it
- Linking Personalized Brain Atrophy to Schizophrenia Network and Treatment Response.Schizophrenia bulletin · 2023Trial
- Connectomic signatures advance the understandings of transdiagnostic heterogeneity in psychosis.Communications medicine · 2026Review
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- Neurophysiological subtyping of schizophrenia reveals a reproducible phenotype with temporoparietal circuit disruptions.General psychiatry · 2026Article
- Toward precision medicine: can neuroimaging prospectively predict early treatment outcomes in schizophrenia spectrum disorders? A systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Review
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting Network Imbalance in Schizophrenia: The Application of Temporal Interference Stimulation.Alpha psychiatry · 2026Article
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2025Article
- Revealing multiple biological subtypes of schizophrenia through a data-driven approach.Journal of translational medicine · 2025Article
- Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis.Schizophrenia bulletin · 2025Review
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- A study of dynamic functional connectivity changes in flight trainees based on a triple network model.Scientific reports · 2025Article
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Biomarker discovery using machine learning in the psychosis spectrum.Biomarkers in neuropsychiatry · 2024Article
- Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning.Biological psychiatry · 2024Review
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a complex disorder associated with aberrant brain functional connectivity. This study aims to demonstrate the relation of heterogeneous symptomatology in this disorder to distinct brain connectivity patterns within the triple-network model. The study sample comprised 300 first-episode antipsychotic-naive patients with schizophrenia (FES) and 301 healthy controls (HCs). At baseline, resting-state functional magnetic resonance imaging data were captured for each participant, and concomitant neurocognitive functions were evaluated outside the scanner. Clinical information of 49 FES in the discovery dataset were reevaluated at a 6-week follow-up. Differential features between FES and HCs were selected from triple-network connectivity profiles. Cutting-edge unsupervised machine learning algorithms were used to define patient subtypes. Clinical and cognitive variables were compared between patient subgroups. Two FES subgroups with differing triple-network connectivity profiles were identified in the discovery dataset and confirmed in an independent hold-out cohort. One patient subgroup appearing to have more severe clinical symptoms was distinguished by salience network (SN)-centered hypoconnectivity, which was associated with greater impairments in sustained attention. The other subgroup exhibited hyperconnectivity and manifested greater deficits in cognitive flexibility. The SN-centered hypoconnectivity subgroup had more persistent negative symptoms at the 6-week follow-up than the hyperconnectivity subgroup. The present study illustrates that clinically relevant cognitive subtypes of schizophrenia may be associated with distinct differences in connectivity in the triple-network model. This categorization may foster further analysis of the effects of therapy on these network connectivity patterns, which may help to guide therapeutic choices to effectively reach personalized treatment goals.
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