Evidence map›Paper›PMID 33408257›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

MyD88 Costimulation in Donor CD8

Nicholas G Ciavattone, Long Wu, Rachel O'Neill, Jingxin Qiu, Eduardo Davila, Xuefang Cao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nicholas G CiavattoneMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201.ORCID 0000-0001-9265-8202
Long WuMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201.
Rachel O'NeillMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201.
Jingxin QiuDepartment of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263; and.
Eduardo DavilaDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0001-9738-4167
Xuefang CaoMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201; xuefangcao@som.umaryland.edu.
University of Maryland, Baltimore · USRoswell Park Comprehensive Cancer Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

CD27/CD70 mediated negative regulation of inflammatory T cell responsesR01HL135325 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2018 to 2021
$2.3M
Targeting Granzyme B to Separate GVH from GVL ResponsesR01CA184728 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2015 to 2019
$1.9M
Augmenting T cell activity to weak tumor antigens and reversing myeloid cell-mediated T cell inhibitionR01CA207913 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI DAVILA, EDUARDO V · 2017 to 2021
$1.9M
Targeting Beta-Adrenergic Signaling to Control GVH and GVL ResponsesR21CA202358 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2016 to 2017
$435k
BLRD VA I01 BX004935NCI NIH HHS R01 CA184728NCI NIH HHS R01 CA207913NCI NIH HHS R21 CA202358NHLBI NIH HHS R01 HL135325
6 · The paper itself

Abstract

Donor-derived lymphocytes from allogeneic hematopoietic cell transplantation (allo-HCT) or donor lymphocyte infusion can mediate eradication of host tumor cells in a process labeled the graft-versus-tumor (GVT) effect. Unfortunately, these treatments have produced limited results in various types of leukemia because of an insufficient GVT effect. In this context, molecular engineering of donor lymphocytes to increase the GVT effect may benefit cancer patients. Activating MyD88 signaling in CD8

Indexed as

Hematopoietic Stem Cell TransplantationLeukemiaAnimalsCD8-Positive T-LymphocytesGraft vs Tumor EffectHumansMiceMyeloid Differentiation Factor 88Transplantation, HomologousMyd88 protein, mouseMyeloid Differentiation Factor 88

Identifiers

PMID33408257
PMCPMC8691539
OpenAlexW3120716423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.