Evidence map›Paper›PMID 33408255›Full record

ArticleThe Journal of experimental biology2021

Rapid toxin sequestration modifies poison frog physiology.

Lauren A O'Connell, LS50: Integrated Science Laboratory Course, Jeremy D O'Connell, Joao A Paulo, Sunia A Trauger, Steven P Gygi, Andrew W Murray

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  7. A toxic environment selects for specialist microbiome in poison frogs.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Convergent evolution of toxin resistance in animals.Biological reviews of the Cambridge Philosophical Society · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lauren A O'ConnellDepartment of Biology, Stanford University, Stanford, CA 94305, USA loconnel@stanford.edu.ORCID 0000-0002-2706-4077
LS50: Integrated Science Laboratory Course
Jeremy D O'ConnellDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Sunia A TraugerHarvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Andrew W MurrayDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-0868-6604
Harvard University · US

Funding

New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Howard Hughes Medical Institute 520008146NIGMS NIH HHS R01 GM067945NIGMS NIH HHS R01 GM132129
6 · The paper itself

Abstract

Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (

Indexed as

ArthropodsPoisonsToxins, BiologicalAnimalsAnuraPredatory BehaviorPoisonsToxins, BiologicalAlkaloidsComplement systemCytochrome P450sProteomicsSaxiphilin

Identifiers

PMID33408255
PMCPMC7888741
OpenAlexW3119938102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.