Evidence map›Paper›PMID 33408246›Full record

ArticleJournal of cell science2021

A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the

Jennifer Michelle Potter-Birriel, Graydon B Gonsalvez, William F Marzluff

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. SLBP-independent control of maternal histone mRNA.bioRxiv : the preprint server for biology · 2026
    Article
  2. Cell-cycle-regulated transcriptional pausing ofMolecular biology of the cell · 2025
    Article
  3. Article
  4. Article
  5. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jennifer Michelle Potter-BirrielCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Graydon B GonsalvezDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912 , USA Marzluff@med.unc.edu ggonsalvez@augusta.edu.ORCID 0000-0002-4458-8497
William F MarzluffCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Marzluff@med.unc.edu ggonsalvez@augusta.edu.ORCID 0000-0003-3635-4073
University of North Carolina at Chapel Hill · USAugusta University · US

Funding

UNC Initiative for Maximizing Student DevelopmentR25GM055336 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN, KASH, THOMAS L. · 1996 to 2023
$12.1M
HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
CONTROL OF HISTONE MRNA SYNTHESISR01GM029832 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOMINSKI, ZBIGNIEW, MARZLUFF, WILLIAM F. · 1985 to 2022
$9.0M
A molecular examination of mRNA localization and cell polarizationR01GM100088 · NIGMS · AUGUSTA UNIVERSITY · PI GONSALVEZ, GRAYDON · 2013 to 2021
$2.7M
NIGMS NIH HHS R01 GM029832NIGMS NIH HHS R01 GM058921NIGMS NIH HHS R01 GM100088NIGMS NIH HHS R25 GM055336
6 · The paper itself

Abstract

Replication-dependent histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending in a stemloop instead of a polyA tail, and are normally regulated coordinately with DNA replication. Stemloop-binding protein (SLBP) binds the 3' end of histone mRNA, and is required for processing and translation. During

Indexed as

Drosophila ProteinsHistonesAnimalsDrosophilamRNA Cleavage and Polyadenylation FactorsNuclear ProteinsRNA-Binding ProteinsRNA, MessengerTumor Suppressor ProteinsDrosophila ProteinsHistonesmRNA Cleavage and Polyadenylation FactorsMxc protein, DrosophilaNuclear ProteinsRNA-Binding ProteinsRNA, MessengerTumor Suppressor ProteinsDrosophila oogenesisHistone locus bodyHistone mRNAMaternal mRNASLBPStemloop-binding protein

Identifiers

PMID33408246
PMCPMC7888719
OpenAlexW3120423114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.