Evidence map›Paper›PMID 33408232›Full record

ArticlemSphere2021

Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein.

Natalie M Barber, Clinton K Y Lau, Louise Turner, Gareth Watson, Susan Thrane, John P A Lusingu, Thomas Lavstsen, Matthew K Higgins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Natalie M Barber *Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Clinton K Y Lau *Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Louise Turner *Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark.
Gareth WatsonDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Susan ThraneCentre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark.
John P A LusinguNational Institute for Medical Research, Dar es Salaam, Tanzania.
Thomas LavstsenCentre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark thomasl@sund.ku.dk matthew.higgins@bioch.ox.ac.uk.ORCID 0000-0002-3044-4249
Matthew K HigginsDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom thomasl@sund.ku.dk matthew.higgins@bioch.ox.ac.uk.ORCID 0000-0002-2870-1955
University of Oxford · GBUniversity of Copenhagen · DKNational Institute for Medical Research · TZ

Funding

Medical Research CouncilWellcome TrustWellcome Trust 101020/Z/13/Z
6 · The paper itself

Abstract

Structure-guided vaccine design provides a route to elicit a focused immune response against the most functionally important regions of a pathogen surface. This can be achieved by identifying epitopes for neutralizing antibodies through structural methods and recapitulating these epitopes by grafting their core structural features onto smaller scaffolds. In this study, we conducted a modified version of this protocol. We focused on the PfEMP1 protein family found on the surfaces of erythrocytes infected with

Indexed as

Amino Acid MotifsAnimalsAntibodies, ProtozoanBinding SitesCell AdhesionEndothelial Protein C ReceptorErythrocytesHumansMalaria, FalciparumPlasmodium falciparumProtein BindingProteinsProtozoan ProteinsRatsAntibodies, ProtozoanEndothelial Protein C Receptorerythrocyte membrane protein 1, Plasmodium falciparumProteinsProtozoan ProteinsEPCRPfEMP1protein design

Identifiers

PMID33408232
PMCPMC7845591
OpenAlexW3120601989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.