Evidence map›Paper›PMID 33408187›Full record

ArticleScience translational medicine2021

Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain.

Qinjie Zhou, Diego F Niño, Yukihiro Yamaguchi, Sanxia Wang, William B Fulton, Hongpeng Jia, Peng Lu, Thomas Prindle, David Pamies, Meaghan Morris and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Host insulin resistance caused byFrontiers in cellular and infection microbiology · 2023
    Pooled it
  2. Article
  3. Necrotizing enterocolitis.Nature reviews. Disease primers · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Qinjie ZhouDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-1321-7490
Diego F NiñoDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-7687-6920
Yukihiro YamaguchiDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.
Sanxia WangDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.
William B FultonDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-5289-1621
Hongpeng JiaDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-6783-7532
Peng LuDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.
Thomas PrindleDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA.
David PamiesCenter for Alternatives to Animal Testing, Johns Hopkins School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-1224-573X
Meaghan MorrisDivision of Neuropathology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5340-148X
Liam L ChenDepartment of Biomedical Science, University of Lausanne, Lausanne, Switzerland.
Chhinder P SodhiDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA. dhackam1@jhmi.edu csodhi@jhmi.edu.
David J HackamDivision of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA. dhackam1@jhmi.edu csodhi@jhmi.edu.ORCID 0000-0001-5195-8807
Bloomberg (United States) · USJohns Hopkins University · USUniversity of Lausanne · CH

Funding

Clinical and Laboratory Research Training for Gastrointestinal SurgeonsT32DK007713 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DAVID J HACKAM · 1996 to 2026
$5.2M
TLR4 Signaling in the Pathogenesis of Surgical Necrotizing EnterocolitisR01GM078238 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HACKAM, DAVID J · 2006 to 2019
$3.9M
The role of ACE2 in Influenza viral infection mediated immune compromise and subsequent bacterial lung infectionR01AI148446 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JIA, HONGPENG · 2020 to 2024
$2.9M
Molecular and metabolic signaling in necrotizing enterocolitisR35GM141956 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI HACKAM, DAVID J · 2021 to 2025
$2.3M
Maternal-Fetal AHR Signaling in the Pathogenesis and Treatment of Necrotizing EnterocolitisR01DK117186 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HACKAM, DAVID J · 2018 to 2021
$1.5M
Enteric Glia Regulation of Intestinal Epithelial TLR4 Signaling In Necrotizing EnterocolitisR01DK121824 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HACKAM, DAVID J · 2020 to 2023
$1.4M
CD43 REGULATION OF IMMUNE RESPONSESR21AI044932 · NIAID · UNIVERSITY OF CHICAGO · PI SPERLING, ANNE I. · 1999 to 1999
–
NIAID NIH HHS R01 AI148446NIAID NIH HHS R21 AI044932NIDDK NIH HHS R01 DK117186NIDDK NIH HHS R01 DK121824NIDDK NIH HHS T32 DK007713NIGMS NIH HHS R01 GM078238NIGMS NIH HHS R35 GM141956
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) causes acute intestinal necrosis in premature infants and is associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in the intestinal epithelium, and NEC-associated brain injury is characterized by microglial activation and white matter loss through mechanisms that remain unclear. We now show that the brains of mice and humans with NEC contained CD4

Indexed as

Enterocolitis, NecrotizingAnimalsBrainInflammationIntestinal MucosaMiceT-Lymphocytes, Regulatory

Identifiers

PMID33408187
PMCPMC8762998
OpenAlexW3119135391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.