ArticleNeurology2021
Prospective Analysis of Leisure-Time Physical Activity in Midlife and Beyond and Brain Damage on MRI in Older Adults.
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In one paragraph
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Long-term physical activity, brain structure, and cognitive function: a systematic review of longitudinal observational evidence.BMC neurology · 2026Pooled it
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Impact of sedentary behavior and physical activity on stroke risk in a cohort of patients with silent brain infarction.Scientific reports · 2026Article
- Plasma miR-34a-5p outperforms miR-126-3p in predicting cognitive decline in cerebral small vessel disease patients with impaired glucose regulation.Frontiers in aging neuroscience · 2026Article
- The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study.European journal of epidemiology · 2026Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Accelerometer-Measured Physical Activity and Neuroimaging-Driven Brain Age.Health data science · 2025Article
- Psychosocial Health and the Association Between Cerebral Small Vessel Disease Markers With Dementia: The ARIC Study.Stroke · 2024Article
- Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage.Stroke and vascular neurology · 2023Article
- Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study.Nutrients · 2023Article
- Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors.Annals of neurology · 2023Article
- Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of Physical Inactivity with MRI Markers of Brain Aging: Assessing Mediation by Cardiometabolic and Epigenetic Factors.Journal of Alzheimer's disease : JAD · 2023Article
- Longitudinal associations of absolute versus relative moderate-to-vigorous physical activity with brain microstructural decline in aging.Neurobiology of aging · 2022Article
- Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses' Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Adherence to Life's Simple 7 and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014.Journal of the American Heart Association · 2022Article
- Social relationships, amyloid burden, and dementia: The ARIC-PET study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Accelerometer-derived daily steps, cognition, and cognitive impairment in U.S. community-dwelling older adults: The Atherosclerosis Risk in Communities Study.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Priya PaltaFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson. pp2464@cumc.columbia.edu.
A Richey SharrettFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Kelley Pettee GabrielFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.ORCID 0000-0003-4986-7927
Rebecca F GottesmanFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Aaron R FolsomFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Melinda C PowerFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Kelly R EvensonFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Clifford R JackFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
David S KnopmanFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Thomas H MosleyFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
Gerardo HeissFrom the Division of General Medicine, Department of Medicine (P.P.), Columbia University Irving Medical Center, New York, NY; Department of Epidemiology (A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Epidemiology, School of Public Health (K.P.G.), The University of Alabama at Birmingham; Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Department of Epidemiology (M.C.P.), Milken Institute School of Public Health, George Washington University, Washington, DC; Department of Epidemiology (K.R.E., G.H.), Gillings School of Global Public Health, University of North Carolina at Chapel Hill; Departments of Radiology (C.R.J.) and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; and The MIND Center (T.H.M.), University of Mississippi Medical Center, Jackson.
University of North Carolina at Chapel Hill · US
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2020 to 2026
$29.3MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5MPhysical Activity and Preservation of Cognitive FunctionR00AG052830 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PALTA, PRIYA · 2019 to 2021
$1.1MNeuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's diseaseK24AG052573 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOTTESMAN, REBECCA F · 2016 to 2020
$803kNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K24 AG052573NIA NIH HHS P30 AG066507NIA NIH HHS R00 AG052830
Abstract
objectiveTo test the hypothesis that greater levels of leisure-time moderate to vigorous intensity physical activity (MVPA) in midlife or late life are associated with larger gray matter volumes, less white matter disease, and fewer cerebrovascular lesions measured in late life, we utilized data from 1,604 participants enrolled in the Atherosclerosis Risk in Communities study.
methodsLeisure-time MVPA was quantified using a past-year recall, interviewer-administered questionnaire at baseline and 25 years later and classified as none, low, middle, and high at each time point. The presence of cerebrovascular lesions, white matter hyperintensities (WMH), white matter integrity (mean fractional anisotropy [FA] and mean diffusivity [MD]), and gray matter volumes were quantified with 3T MRI in late life. The odds of cerebrovascular lesions were estimated with logistic regression. Linear regression estimated the mean differences in WMH, mean FA and MD, and gray matter volumes.
resultsAmong 1,604 participants (mean age 53 years, 61% female, 27% Black), 550 (34%), 176 (11%), 250 (16%), and 628 (39%) reported no, low, middle, and high MVPA in midlife, respectively. Compared to no MVPA in midlife, high MVPA was associated with more intact white matter integrity in late life (mean FA difference 0.13 per SD [95% confidence interval (CI) 0.004, 0.26]; mean MD difference -0.11 per SD [95% CI -0.21, -0.004]). High MVPA in midlife was also associated with a lower odds of lacunar infarcts (odds ratio 0.68, 95% CI 0.46, 0.99). High MVPA was not associated with gray matter volumes. High MVPA compared to no MVPA in late life was associated with most brain measures.
conclusionGreater levels of physical activity in midlife may protect against cerebrovascular sequelae in late life.
Indexed as
Leisure ActivitiesBrainExerciseFemaleGray MatterHumansLeukoencephalopathiesMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingOrgan SizeWhite Matter
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