ArticleProceedings of the National Academy of Sciences of the United States of America2021
Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 108 citations in OpenAlex.
- Passive Metasurface Tweezers for Multi-Scale Orbital Transport and Trapping on Elastic Plates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Machine learning-facilitated real-time acoustic trapping in time-varying multi-medium environments toward magnetic resonance imaging-guided microbubble manipulation.Communications engineering · 2026Article
- Focused Ultrasound-Triggered Burst Release and Enrichment of Engineered Bacteria for Tumor Therapy.Biomaterials research · 2026Article
- Remote biofilm dislodgment using focused acoustic vortex.Ultrasonics sonochemistry · 2025Article
- Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex.Ultrasonics sonochemistry · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Topological-charge multiplexed metasurfaces for generating structural acoustic field and remote dynamic control.Science advances · 2025Article
- Synergistic sonothrombolysis based on coaxial confocal dual-frequency focused ultrasound and vortex beams.Ultrasonics sonochemistry · 2025Article
- Ultrasound-cavitation-enhanced drug delivery via microbubble clustering induced by acoustic vortex tweezers.Ultrasonics sonochemistry · 2025Article
- Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation.Nature communications · 2025Article
- Hierarchical Nanostructures as Acoustically Manipulatable Multifunctional Agents in Dynamic Fluid Flow.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Acoustofluidic tweezers via ring resonance.Science advances · 2024Article
- Tunable Acoustic Tweezer System for Precise Three-Dimensional Particle Manipulation.Micromachines · 2024Article
- Machine Learning-Empowered Real-Time Acoustic Trapping: An Enabling Technique for Increasing MRI-Guided Microbubble Accumulation.Sensors (Basel, Switzerland) · 2024Article
- Airborne Acoustic Vortex End Effector-based Contactless, Multi-mode, Programmable Control of Object Surfing.Advanced materials technologies · 2024Article
- Acoustic Actuators for the Manipulation of Micro/Nanorobots: State-of-the-Art and Future Outlooks.Micromachines · 2024Review
- Article
- Bioinspired self-assembled colloidal collectives drifting in three dimensions underwater.Science advances · 2023Article
- Acoustic diffraction-resistant adaptive profile technology (ADAPT) for elasticity imaging.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatially concentrating and manipulating biotherapeutic agents within the circulatory system is a longstanding challenge in medical applications due to the high velocity of blood flow, which greatly limits drug leakage and retention of the drug in the targeted region. To circumvent the disadvantages of current methods for systemic drug delivery, we propose tornado-inspired acoustic vortex tweezer (AVT) that generates net forces for noninvasive intravascular trapping of lipid-shelled gaseous microbubbles (MBs). MBs are used in a diverse range of medical applications, including as ultrasound contrast agents, for permeabilizing vessels, and as drug/gene carriers. We demonstrate that AVT can be used to successfully trap MBs and increase their local concentration in both static and flow conditions. Furthermore, MBs signals within mouse capillaries could be locally improved 1.7-fold and the location of trapped MBs could still be manipulated during the initiation of AVT. The proposed AVT technique is a compact, easy-to-use, and biocompatible method that enables systemic drug administration with extremely low doses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.