ArticleBJPsych open2021
An exploratory study of perinatal hair cortisol concentrations in mother-infant dyads with severe psychiatric disorders versus healthy controls.
Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Stress in lockdown: exploring the interplay and effects of cortisol and psychological distress in parent-child dyads.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Using Machine Learning to Identify Predictors of Maternal and Infant Hair Cortisol Concentration Before and During the COVID-19 Pandemic.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders.Archives of women's mental health · 2024Article
- Intergenerational impact of childhood trauma on hair cortisol concentrations in mothers and their young infants.Comprehensive psychoneuroendocrinology · 2023Article
- Associations between Maternal and Offspring Hair Cortisol Concentrations and Child Behavioral Symptoms in Mother-Child Pairs with Perinatal Mental Disorders.Children (Basel, Switzerland) · 2022Article
- Parental Stress and Scalp Hair Cortisol in Excessively Crying Infants: A Case Control Study.Children (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal psychopathology during pregnancy is associated with negative outcomes in offspring. Increased placental transfer of maternal cortisol may contribute to mediate this association. Hair cortisol concentrations (HCCs) appear to be a good biomarker of long-term prenatal stress exposure. Little is known about the associations between severe maternal psychopathology and perinatal infant HCCs.
aimsWe assessed HCCs in the perinatal period in mother-infant dyads with and without severe psychiatric disorders.
methodWe examined group differences in HCCs of mother-infant dyads (n = 18) subjected to severe maternal psychiatric disorders versus healthy control dyads (n = 27). We assessed the correlation of HCCs between mother and infant within both groups, and the association between current maternal symptoms and HCCs in patient dyads.
resultsMedian (interquartile range) and distribution of HCC differed in patients compared with control mothers (U = 468.5, P = 0.03). HCCs in infants of patients did not differ from control infants (U = 250.0, P = 0.67). Subsequently, we found that HCCs within healthy control dyads were correlated (n = 27, r 0.55 (0.14), P = 0.003), but were not within patient dyads (n = 18, r 0.082 (0.13), P = 0.746). HCCs in infants of patients showed a positive correlation with maternal symptoms (n = 16, r = 0.63 (0.06), P = 0.008).
conclusionsThese preliminary findings suggest that infant HCC reflect perinatal stress exposure. In infants, these early differences could influence lifetime hypothalamic-pituitary-adrenal axis functioning, which might be associated with increased susceptibility to later disease.
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