Evidence map›Paper›PMID 33407950›Full record

ArticlePilot and feasibility studies2021

Mobile telephone delivered contingency management for encouraging adherence to supervised methadone consumption: feasibility study for an RCT of clinical and cost-effectiveness (TIES).

N Metrebian, E Carr, K Goldsmith, T Weaver, S Pilling, J Shearer, K Woolston-Thomas, B Tas, C Cooper, C A Getty and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

N MetrebianKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK. nicola.metrebian@kcl.ac.uk.
E CarrKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
K GoldsmithKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
T WeaverDepartment of Mental Health, Social Work and Integrative Medicine, School of Health and Education, Middlesex University, London, NW4 4BT, UK.
S PillingResearch Department of Clinical Health and Educational Psychology, University College London, London, WC1 7HB, UK.
J ShearerKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
K Woolston-ThomasKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
B TasKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
C CooperKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
C A GettyKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
R van der WaalCentral Acute and Addictions Directorate, South London and Maudsley NHS Foundation Trust, London, SE5 8RS, UK.
M KelleherCentral Acute and Addictions Directorate, South London and Maudsley NHS Foundation Trust, London, SE5 8RS, UK.
E FinchCentral Acute and Addictions Directorate, South London and Maudsley NHS Foundation Trust, London, SE5 8RS, UK.
P BijralChange, Grow, Live Charity, Management Offices, M4 1NA, Manchester, UK.
D TaylorCentral Acute and Addictions Directorate, South London and Maudsley NHS Foundation Trust, London, SE5 8RS, UK.
J ScottUniversity of Bath, BAA2 7AY, Bath, UK.
J StrangKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AB, UK.
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GBMiddlesex University · GBUniversity College London · GBUniversity of Bath · GB

Funding

National Institute for Health Research PB-PG-0815-20053
6 · The paper itself

Abstract

backgroundPrescription methadone or buprenorphine enables people with opioid use disorder to stop heroin use safely while avoiding withdrawal. To ensure methadone is taken as prescribed and to prevent diversion onto the illicit market, people starting methadone take their daily dose under a pharmacist's supervision. Many patients miss their daily methadone dose risking withdrawal, craving for heroin and overdose due to loss of heroin tolerance. Contingency management (CM) can improve medication adherence, but remote delivery using technology may be resource-light and cost-effective. We developed an innovative way to deliver CM by mobile telephone. Software monitors patients' attendance and supervised methadone consumption through an internet self-login at the pharmacy and sends reinforcing text messages to patients' mobile telephones. A linked system sends medication adherence reports to prescribers and provides early warning alerts of missed doses. A pre-paid debit card system provides financial incentives.

methodsA cluster randomised controlled trial design was used to test the feasibility of conducting a future trial of mobile telephone CM to encourage adherence to supervised methadone in community pharmacies. Each cluster (drug service/3 allied pharmacies) was randomly allocated to provide patient's presenting for a new episode of opiate agonist treatment (OAT) with either (a) mobile telephone text message CM, (b) mobile telephone text message reminders, or (c) no text messages. We assessed acceptability of the interventions, recruitment, and follow-up procedures.

resultsFour drug clinics were approached and three recruited. Thirty-three pharmacists were approached and 9 recruited. Over 3 months, 173 individuals were screened and 10 enrolled. Few patients presented for OAT and high numbers were excluded due to receiving buprenorphine or not attending participating pharmacies. There was 96% consistency in recording medication adherence by self-login vs. pharmacy records. In focus groups, CM participants were positive about using self-login, the text messages, and debit card. Prescribers found weekly reporting, time saving, and allowed closer monitoring of patients. Pharmacists reported that the tablet device was easy to host.

conclusionMobile telephone CM worked well, but a planned future trial will use modified eligibility criteria (existing OAT patients who regularly miss their methadone/buprenorphine doses) and increase the number of participating pharmacies.

trial registrationThe trial is retrospectively registered, ISRCTN 58958179 .

Indexed as

Contingency managementMedication adherenceMobile telephoneOpioid agonist treatment

Identifiers

PMID33407950
PMCPMC7789356
OpenAlexW3120295479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.