Evidence map›Paper›PMID 33407940›Full record

ArticleCerebellum & ataxias2021

Cerebellar ataxia and exercise intolerance in Erdheim-Chester disease.

Eleonora Lauricella, Antonio d'Amati, Giuseppe Ingravallo, Maurizio Foresio, Domenico Ribatti, Marina de Tommaso, Mauro Cives, Francesco Girolamo

Open access · hybridAbstract read
In one paragraph

Article in Cerebellum & ataxias, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eleonora LauricellaDepartment of Biomedical Sciences and Human Oncology, Clinical Oncology Section, University of Bari School of Medicine, Bari, Italy.
Antonio d'AmatiDepartment of Emergency and Organ Transplantation (D.E.T.O.), Pathology Section, University of Bari School of Medicine, Bari, Italy.
Giuseppe IngravalloDepartment of Emergency and Organ Transplantation (D.E.T.O.), Pathology Section, University of Bari School of Medicine, Bari, Italy.
Maurizio ForesioU.O.C. Urologia, Ospedale SS Annunziata, Taranto, Italy.
Domenico RibattiDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Human Anatomy Section, University of Bari School of Medicine, Policlinico Universitario, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
Marina de TommasoDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Human Anatomy Section, University of Bari School of Medicine, Policlinico Universitario, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
Mauro CivesDepartment of Biomedical Sciences and Human Oncology, Clinical Oncology Section, University of Bari School of Medicine, Bari, Italy.
Francesco GirolamoDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Human Anatomy Section, University of Bari School of Medicine, Policlinico Universitario, Piazza Giulio Cesare, 11, 70124, Bari, Italy. francesco.girolamo@uniba.it.ORCID http://orcid.org/0000-0001-8706-3386
University of Bari Aldo Moro · ITIstituto Tumori Bari · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundErdheim-Chester disease (ECD), a rare disorder of monocyte/macrophage lineage, has been related to cerebellar dysfunction. To increase the awareness of this rare, protean disease, an unusual, myasthenia-like onset of ECD is reported. CASE PRESENTATION: A 42-year-old man presented with a 6-year history of mild evening fatigability in his four limbs followed by motor and cognitive symptoms associated with cerebellar atrophy, dentate nuclei and dentato-thalamic pathway degeneration. Magnetic resonance imaging revealed hyperintense signals in T2 and fluid-attenuated inversion recovery sequences within the pons, cerebellar white matter, dentate nuclei and globi pallidi in the absence of any contrast enhancement. Whole-body bone scintigraphy with

conclusionIn patients with myasthenia-like symptoms who test negatively for myasthenia gravis, neurodegenerative diseases, and disorders of the hypothalamus, a diagnosis of ECD should be taken into consideration.

Indexed as

AtaxiaCerebellar atrophy Cognitive impairmentErdheim-Chester diseaseFatigabilityHistiocytosis

Identifiers

PMID33407940
PMCPMC7789415
OpenAlexW3119566976

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.