Evidence map›Paper›PMID 33407922›Full record

ReviewJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2021

Prehabilitation in head and neck cancer patients: a literature review.

Irene Loewen, Caroline C Jeffery, Jana Rieger, Gabriela Constantinescu

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06785051 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of AI-Based Physiotherapy on Mandibular Mobility, Shoulder Function, Whole-Body Physical Function, and Quality of Life in Oral Cancer Patients

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2027Enrolled100ConditionsOral CancerArmsAI-based physiotherapy, Conventional physiotherapy, Scar management
NCT07237672 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of AI Based Physiotherapy on Mandibular Mobility Shoulder Function Whole Body Physical Function Quality of Life and Return to Work in Oral Cancer Patients: 3- and 9-Month Postintervention Follow-Up

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2027Enrolled65ConditionsOral CancerArmsAI-based physiotherapy follow-up assessments, conventional physiotherapy follow-up assessments
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Evaluation of physical rehabilitation in patients receiving curative treatment for head and neck cancer: The NUTRIMOUV randomized phase II trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  4. Trial
  5. Article
  6. Prehabilitation in Head and Neck Surgery and Reconstruction.Plastic and reconstructive surgery. Global open · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Patients' experiences of dysphagia and rehabilitation care needs across the pre-, intra-, and post-radiotherapy phases for head and neck cancer: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Irene LoewenDepartment of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, 8205 114St 2-70 Corbett Hall, Edmonton, Alberta, T6R 3T5, Canada.
Caroline C JefferyFaculty of Medicine and Dentistry, Division of Otolaryngology - Head and Neck Surgery, University of Alberta, Edmonton, AB, Canada.
Jana RiegerDepartment of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, 8205 114St 2-70 Corbett Hall, Edmonton, Alberta, T6R 3T5, Canada.
Gabriela ConstantinescuDepartment of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, 8205 114St 2-70 Corbett Hall, Edmonton, Alberta, T6R 3T5, Canada. constant@ualberta.ca.ORCID http://orcid.org/0000-0001-7709-6547
University of Alberta · CA

Funding

Covenant Health Research Grant 11007
6 · The paper itself

Abstract

backgroundDysphagia is one consequence of head and neck cancer that has a significant impact on quality of life for head and neck cancer survivors. While survival rates continue to improve, focus has shifted to maximizing long-term function, with prevention or prehabilitation programs becoming more common. Prehabilitation programs typically include an exercise regime that specifies the exercise type, the number of repetitions to complete per set, the number of sets of each exercise to complete per day, as well as the length of the treatment block. Ideally, exercise programs are designed with principles of neuromuscular plasticity in mind.

methodsTwenty-nine original research articles published between 2006 and 2020 were included in this state-of-the-art review and examined for program timing and details.

resultsTwo definitions for prehabilitation were noted: one third of the studies defined prehabilitation as preventative exercises prior to the start of acute cancer treatment; the remaining two thirds defined prehabilitation as treatment concurrent prehabilitation. Exercises prescribed ranged from general stretching and range of motion exercises, to trismus and swallowing specific exercises. The most common swallowing specific exercise was the Mendelsohn's maneuver, followed by the effortful swallow, Shaker, and Masako maneuver. The most common dose was 10 repetitions of an exercise, three times per day for the duration of radiation therapy. The most common measures were questionnaires, followed by g-tube dependence, mouth opening, and MBS reports.

conclusionThis review of the literature has shed light on the variability of prehabilitation timing, exercise type, dose, duration of treatment, and outcomes associated with prehabilitation, making the selection of an optimal prehabilitation program difficult at this time.

Indexed as

Preoperative ExerciseChemoradiotherapyDeglutition DisordersHead and Neck NeoplasmsHumansPostoperative ComplicationsDeglutitionDysphagiaExerciseHead and neck cancerPrehabilitationPreventativeProphylacticReview

Identifiers

PMID33407922
PMCPMC7789666
OpenAlexW3118271070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.