Evidence map›Paper›PMID 33407727›Full record

ArticleTrials2021

Efficacy of simultaneous aerobic exercise and cognitive training in subjective cognitive decline: study protocol for randomized controlled trial of the Exergames Study.

Dereck Salisbury, Tom Plocher, Fang Yu

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04311736 (Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04311736 naunknown statusnot on this map

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergame Study)

TypeinterventionalSponsorMoai Technologies LLCRan2019 to 2021Enrolled96ConditionsMild Cognitive Impairment, Exercise TrainingArmsExergame, Cycling, Stretching
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dereck SalisburyUniversity of Minnesota School of Nursing, 5-160 WDH 1331, 308 Harvard St SE, Minneapolis, MN, 55455, USA. salis048@umn.edu.ORCID http://orcid.org/0000-0002-0117-2643
Tom PlocherMoai Technologies LLC, Minneapolis, MN, USA.
Fang YuUniversity of Minnesota School of Nursing, 5-160 WDH 1331, 308 Harvard St SE, Minneapolis, MN, 55455, USA. yuxxx244@umn.edu.
University of Minnesota · USMoai Technologies (United States) · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer’s in at-risk Older AdultsR44AG055176 · NIA · MOAI TECHNOLOGIES, LLC · PI PLOCHER, TOM, YU, FANG · 2016 to 2019
$1.7M
NCATS NIH HHS UL1 TR000114NIA NIH HHS 4R44AG055176-02NIA NIH HHS R44 AG055176
6 · The paper itself

Abstract

backgroundSubjective cognitive decline (SCD) is an early manifestation of Alzheimer's disease (AD) and offers a therapeutic window where interventions have strong potential to prevent or delay the progression of AD. Aerobic exercise and cognitive training represent two promising interventions for AD prevention, but their synergistic effect has yet to be assessed in persons with SCD. METHODS/

designThe purpose of this single-blinded, 3-parallel group randomized controlled trial is to test the synergistic efficacy of an exergame intervention (simultaneous moderate-intensity aerobic cycling and cognitive training) on cognition and aerobic fitness in community-dwelling older adults with SCD. The Exergames Study will randomize 96 participants on a 2:1:1 allocation ratio to 3-month exergame, cycling only, or attention control (stretching). Primary outcomes include global cognition and aerobic fitness, which will be assessed at baseline and after 3 months. The specific aims of the Exergames Study are to (1) determine the efficacy of the exergame in older adults with SCD and (2) assess the distraction effect of exergame on aerobic fitness. Data will be analyzed using ANOVA following intention-to-treat. DISCUSSION: This study will test the synergistic effects of exergame on cognition and aerobic fitness. It has the potential to advance prevention research for AD by providing effect-size estimates for future trials.

trial registrationClinicalTrials.gov NCT04311736 . Registered on 17 March 2020.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedCognitionExerciseExercise TherapyHumansRandomized Controlled Trials as TopicTreatment OutcomeAerobic exerciseAlzheimer’s diseaseCognitionCognitive trainingExerciseSubjective cognitive decline

Identifiers

PMID33407727
PMCPMC7788690
OpenAlexW3120489485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.