ArticleMolecular brain2021
Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort.
Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.Journal of the American Heart Association · 2024Article
- Review
- Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study.Drug and alcohol dependence · 2023Article
- Article
- eQTLs as causal instruments for the reconstruction of hormone linked gene networks.Frontiers in endocrinology · 2022Review
- Genetic Variation and Mendelian Randomization Approaches.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.
methodsThe SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.
resultsWe observed positive association between SHBG and the frequency of alcohol consumption (b = 0.0101, p = 3.84 × 10
conclusionOur study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.
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Registered trials
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