ArticleNutrition & metabolism2021
Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats.
Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Comparative evaluation of the gastroprotective effects of lactic acid bacteria strains against ethanol/HCl-induced gastric injury.Food science of animal resources · 2026Article
- Mechanism of action of heat-clearing and detoxifying herbs in the treatment of erosive gastritis.World journal of gastroenterology · 2025Review
- The effects of acetylsalicylic acid on performance, carcass traits, breast meat quality and white striping muscle defects in broiler chickens.Journal of the science of food and agriculture · 2025Article
- Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Exploring phytochemicals and their pharmacological applications from ethnomedicinal plants: A focus onHeliyon · 2025Review
- Protective effect ofMicrobiology spectrum · 2024Article
- CombinedPharmaceuticals (Basel, Switzerland) · 2023Article
- The role of microbiomes in gastrointestinal cancers: new insights.Frontiers in oncology · 2023Review
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- Dietary Supplementation with Goji Berries (Animals : an open access journal from MDPI · 2022Article
- Recent Studies on Berry Bioactives and Their Health-Promoting Roles.Molecules (Basel, Switzerland) · 2021Review
- Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms.Frontiers in nutrition · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNon-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats.
methodsMale Sprague-Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks.
resultsThe MIX group elevated gastric cyclooxygenase-1, prostaglandin E
conclusionsWe conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.
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