Evidence map›Paper›PMID 33407578›Full record

ArticleThrombosis journal2021

Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization.

Franca Del Nonno, Daniele Colombo, Roberta Nardacci, Laura Falasca

Abstract read
In one paragraph

Article in Thrombosis journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. COVID-19 bimodal clinical and pathological phenotypes.Clinical and translational medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Franca Del NonnoPathology Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Daniele ColomboPathology Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Roberta NardacciLaboratory of Electron Microscopy, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy. roberta.nardacci@inmi.it.ORCID http://orcid.org/0000-0002-9209-1207
Laura FalascaLaboratory of Electron Microscopy, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.

Funding

Ministero della Salute COVID-2020-12371675Ministero della Salute COVID-2020-12371817Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

backgroundA considerable number of SARS-CoV-2 infected individuals could be asymptomatic and don't need medical treatment. The clinical spectrum of SARS-CoV-2 infection ranges from asymptomatic cases, medium-intensity forms with mild to moderate symptoms, to severe ones with bilateral pneumonia and respiratory distress. In cases with severe presentation of SARS-CoV-2 infection, the induction of hypercoagulability is one of the pathophysiological mechanism that can contribute to death. CASE PRESENTATION: Here, we reported autoptic evidences of thrombotic pulmonary arterial fatal lesions in an asymptomatic COVID-19 patient, after swab negativization. Whole body complete post-mortem examination was performed, showing the presence of a large thrombus occluding the main pulmonary artery that was the cause of death. Histopathological analysis showed heterogeneous pattern of pathological changes in the lung tissue with numerous vascular thrombi, inflammatory cardiomyopathy and other histopathological modifications in kidneys, spleen and liver.

conclusionsThis study provides evidences that also asymptomatic patients may be at risk to develop thrombotic complications. An appropriate diagnostic screening for thrombotic complications and the early treatment recommendations of antithrombotic drugs could represent an important topic even in asymptomatic individuals.

Indexed as

AsymptomaticCOVID-19HeartLungSARS-CoV-2Thrombosis

Identifiers

PMID33407578
PMCPMC7785914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.