Evidence map›Paper›PMID 33407547›Full record

Trial reportHealth and quality of life outcomes2021

Chinese pediatric Tuina on children with acute diarrhea: a randomized sham-controlled trial.

Taoying Lu, Lingjia Yin, Ruoqing Chen, Huiyan Zhang, Jianxiong Cai, Meiling Li, Lin Dai, Conghao Zhu, Yongping Zhang, Feng Xiang and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03005821 (Chinese Pediatric Massage on Children With Acute Diarrhea), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03005821 nacompletednot on this map

Chinese Pediatric Massage on Children With Acute Diarrhea: a Randomized Sham Massage Controlled Trial

TypeinterventionalSponsorGuangzhou University of Traditional Chinese MedicineRan2017 to 2019Enrolled84ConditionsDiarrheaArmsChinese pediatric massage therapy + usual care, Sham massage therapy + usual care
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Parental Experiences of Administering PediatricJMIR pediatrics and parenting · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Taoying LuState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, PO Box 510120, 111 Dade Road, Guangzhou, China.
Lingjia YinProgram for Outcome Assessment in TCM, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, PO Box 510120, 111 Dade Road, Guangzhou, China.
Ruoqing ChenClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Huiyan ZhangTCM-Integrated Hospital of Southern Medical University, Guangzhou, China.
Jianxiong CaiProgram for Outcome Assessment in TCM, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, PO Box 510120, 111 Dade Road, Guangzhou, China.
Meiling LiGastroenterology Department, Guangzhou Hospital of TCM, Guangzhou, China.
Lin DaiAcupuncture and Tuina Department, Wenzhou Hospital of Chinese Medicine, Wenzhou, China.
Conghao ZhuPediatric Department, Dongguan Kanghua Hospital, Dongguan, China.
Yongping ZhangPediatric Department, Dongguan Kanghua Hospital, Dongguan, China.
Feng XiangPediatric Department, Dongguan Kanghua Hospital, Dongguan, China.
Li WangPediatric Department, Dongguan Kanghua Hospital, Dongguan, China.
Lu LiPediatric Department, Dongguan Kanghua Hospital, Dongguan, China.
Lixin WangDepartment of Tuina, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Darong WuState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, PO Box 510120, 111 Dade Road, Guangzhou, China. darongwu@gzucm.edu.cn.ORCID http://orcid.org/0000-0003-3159-7359

Funding

Clinical Pathway Project of Guangdong Provincial Hospital of Chinese Medicine, China 2015, No.119The National Key R&D Program of China No.2019YFC1709800/No.2019YFC1709802The Science and Technology Planning Project of Guangdong Province, China No.2013B032500014
6 · The paper itself

Abstract

backgroundPediatric Tuina has been widely used in children with acute diarrhea in China. However, due to the lack of high-quality clinical evidence, the benefit of Tuina as a therapy is not clear. We aimed to assess the effect of pediatric Tuina compared with sham Tuina as an add-on therapy in addition to usual care for 0-6-year-old children with acute diarrhea.

methodsEighty-six participants aged 0-6 years with acute diarrhea were randomized to receive pediatric Tuina plus usual care (n = 43) or sham Tuina plus usual care (n = 43). The primary outcomes were days of diarrhea from baseline and times of diarrhea on day 3. Secondary outcomes included a global change rating (GCR) and the number of days when the stool characteristics returned to normal. Adverse events were assessed.

resultsPediatric Tuina was associated with a reduction in times of diarrhea on day 3 compared with sham Tuina in both ITT (crude RR, 0.73 [95% CI, 0.59-0.91]) and PP analyses (crude RR, 0.66 [95% CI, 0.53-0.83]). However, the results were not significant when we adjusted for social demographic and clinical characteristics. No significant difference was found between groups in days of diarrhea, global change rating, or number of days when the stool characteristics returned to normal.

conclusionsIn children aged 0-6 years with acute diarrhea, pediatric Tuina showed significant effects in terms of reducing times of diarrhea compared with sham Tuina. Studies with larger sample sizes and adjusted trial designs are warranted to further evaluate the effect of pediatric Tuina therapy.

trial registrationClinicaltrials.gov, Identifier: NCT03005821 , Data of registration: 2016-12-29.

Indexed as

Complementary TherapiesAcute DiseaseChildChild, PreschoolChinaDiarrheaDiarrhea, InfantileDouble-Blind MethodFemaleHumansInfantInfant, NewbornMaleMedicine, Chinese TraditionalAcute diarrheaChildrenPediatric TuinaSham Tuina

Identifiers

PMID33407547
PMCPMC7788799

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.